原发性肿瘤的[F]FDG PET/CT参数在评估伴有cN1 - cN3淋巴结受累的非小细胞肺癌患者总生存中的价值。
Value of [F]FDG PET/CT parameters of the primary tumor in assessing overall survival in NSCLC patients with cN1-cN3 lymph nodes involvement.
作者信息
Cegla Paulina, Hofheinz Frank, Czepczyński Rafał, Witkowska Kamila, van den Hoff Jörg, Trojanowski Maciej, Bos-Liedke Agnieszka, Cholewinski Witold
机构信息
Department of Nuclear Medicine, Greater Poland Cancer Centre, Poznan, Poland.
Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.
出版信息
Rep Pract Oncol Radiother. 2024 Mar 18;29(1):97-102. doi: 10.5603/rpor.99360. eCollection 2024.
BACKGROUND
The aim of this retrospective study was to assess the value of F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ([F]FDG PET/CT parameters in cN1-cN3 non-small cell lung cancer (NSCLC) patients.
MATERIALS AND METHODS
59 consecutive patients (35 M, 24 F) with NSCLC who underwent pretreatment [F]FDG PET/CT were enrolled to this study. Several primary tumor PET parameters, including the maximum and mean standardized uptake value (SUV and SUV, the metabolic active tumor volume (MTV) and the total lesion glycolysis (TLG = MTVxSUV), were extracted and analysed. Overall survival was defined as time from primary diagnosis to death or the last info.
RESULTS
In the whole analysed group 44 patients underwent curative treatment, while 15, because of the severity of the disease, were classified for palliative treatment. Univariate Cox analysis of clinical and metric PET parameters revealed that MTV was a significant prognostic factor for OS (p = 0.024), while TLG and curative treatment showed a trend for significance (p < 0.1). In multivariate Cox regression (MTV and curative treatment) MTV remained a significant factor (p = 0.047).
CONCLUSIONS
Metabolic tumor volume of the primary tumor was the only independent prognostic factor for cN1-cN3 NSCLC patients.
背景
本回顾性研究的目的是评估F-氟-2-脱氧-D-葡萄糖正电子发射断层扫描/计算机断层扫描（[F]FDG PET/CT）参数在cN1-cN3期非小细胞肺癌（NSCLC）患者中的价值。
材料与方法
本研究纳入了59例连续接受治疗前[F]FDG PET/CT检查的NSCLC患者（35例男性，24例女性）。提取并分析了几个原发性肿瘤PET参数，包括最大和平均标准化摄取值（SUVmax和SUVmean）、代谢活性肿瘤体积（MTV）和总病变糖酵解（TLG = MTV×SUVmean）。总生存期定义为从初次诊断到死亡或最后一次随访的时间。
结果
在整个分析组中，44例患者接受了根治性治疗，而15例由于病情严重被归类为姑息性治疗。对临床和PET测量参数进行单因素Cox分析显示，MTV是总生存期的显著预后因素（p = 0.024），而TLG和根治性治疗显示出显著趋势（p < 0.1）。在多因素Cox回归分析（MTV和根治性治疗）中，MTV仍然是一个显著因素（p = 0.047）。
结论
原发性肿瘤的代谢肿瘤体积是cN1-cN3期NSCLC患者唯一的独立预后因素。
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