Effects of Transverse Abdominis Plane (TAP) Block on the MAC of Sevoflurane in Gynecologic Patients with Laparoscopic Pneumoperitoneal Stimulation: An Up-Down Sequential Allocation Study.

PURPOSE

This study aimed to observe the effect of bilateral transverse abdominis plane (TAP) block on the MAC of sevoflurane in gynecological patients with laparoscopic pneumoperitoneal stimulation.

PATIENTS AND METHODS

Fifty patients who underwent laparoscopic surgery were randomly assigned to either the control group (= 25) or the TAP block group (= 25). Patients in the TAP block group were subjected to a bilateral transversal abdominal muscle plane block with 0.33% ropivacaine (20 mL on each side) guided by ultrasound. The control group received an equal volume of normal saline. The MAC of sevoflurane in each group was determined using a sequential allocation technique.

RESULTS

The MAC of sevoflurane in the TAP block group was significantly lower than that in the control group (4.20% [95% confidence interval {CI}, 4.02%-4.38%] vs 5.03% [95% CI, 4.89%-5.18%]).

CONCLUSION

Bilateral TAP block can reduce the MAC of sevoflurane in gynecological patients with pneumoperitoneum stimulation.

TRIAL REGISTRATION NUMBER

ChiCTR2100046517. The trial is publicly available and registered at www.chictr.org.cn on May 18, 2021.