Stanojkovic Tijana, Zivkovic Zaric Radica, Lesnjak Ivana, Gajic Milan, Markovic Srecko, Canovic Aleksandar, Jankovic Jovanovic Katarina
Department of Pharmacology and Toxicology, University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia.
Medical Military Academy, Belgrade, Serbia.
Psychiatry Clin Psychopharmacol. 2024 Jun 1;34(2):103-108. doi: 10.5152/pcp.2024.23778. eCollection 2024 Jun.
Isotretinoin is an oral medicine prescribed for the management of severe acne that is insensitive to conventional therapy, including systemic antibiotics. Acute psychosis refers to a severe mental illness characterized by a loss of touch with realism, visions, delusions, confused thinking, and abnormal behaviors. The study aims to analyze and document these cases to better understand the potential relationship between isotretinoin use and the development of acute psychosis, as well as to find out which therapy is best for treating this problem.
We searched the following electronic databases independently with no linguistic or date limit: PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, and Serbian Citation Index (SCIndeks).
Our results included 14 studies (13 case reports and 1 cohort study) with 18 individual cases. The oldest patient was 27 years old, and the youngest was 13 years old. Both genders were represented with 9 individuals each.
We can conclude that, in addition to discontinuation of isotretinoin, therapy with olanzapine and eventually risperidone could improve the symptoms of psychosis caused by isotretinoin.
异维A酸是一种口服药物，用于治疗对包括全身用抗生素在内的传统疗法不敏感的重度痤疮。急性精神病是一种严重的精神疾病，其特征是与现实脱节、幻觉、妄想、思维混乱和行为异常。本研究旨在分析并记录这些病例，以更好地理解使用异维A酸与急性精神病发生之间的潜在关系，以及找出治疗该问题的最佳疗法。
我们独立检索了以下电子数据库，无语言或日期限制：PubMed/MEDLINE、Scopus、科学网、谷歌学术和塞尔维亚引文索引（SCIndeks）。
我们的结果包括14项研究（13例病例报告和1项队列研究），共18例个体病例。年龄最大的患者为27岁，最小的为13岁。男女各9例。
我们可以得出结论，除停用异维A酸外，使用奥氮平并最终使用利培酮进行治疗可改善异维A酸所致精神病的症状。
