Turk Psikiyatri Derg. 2021 Fall;32(3):214-218. doi: 10.5080/u25066.
Biological, genetic and psychosocial factors may play a role in the aetiology of bipolar mood disorder (BPD). BPD episodes might be triggered by isotretinoin, a retinoid derivative of vitamin A with a role in cellular proliferation and differentiation. Due to its association with depression, suicidal ideation and suicide attempts, American Food and Drug Administration (FDA) issued a placement of a label warning for isotretionin. Personal or family history of psychiatric disorders was emphasized in the literature for the risk of mood episodes following isotretionin treatment. Here we aim to present the case of an 18- year old young male adult, without personal or family history of a psychiatric disorder, who developed psychotic mania within the first week of isoretinoin which was prescribed for acne vulgaris. Psychotic mania symptoms receded within one week after starting olanzapine (10 mg/day). We believe this case is significant in demonstrating the occurence of a manic episode after isoretinoin in individuals lacking a personal or family history of psychiatric diagnoses.
生物学、遗传学和社会心理因素可能在双相情感障碍（BPD）的病因学中起作用。BPD 发作可能由异维 A 酸触发，异维 A 酸是维生素 A 的一种类视黄醇衍生物，在细胞增殖和分化中起作用。由于异维 A 酸与抑郁、自杀意念和自杀企图有关，美国食品和药物管理局（FDA）发布了关于异维 A 酸的标签警告。文献强调了个人或家族精神病史在异维 A 酸治疗后发生情绪发作的风险。在这里，我们旨在介绍一例 18 岁成年男性的病例，该患者无个人或家族精神病史，在因痤疮而开异维 A 酸的第一周内出现精神病性躁狂。在开始服用奥氮平（10 毫克/天）后一周内，精神病性躁狂症状消退。我们认为，在缺乏个人或家族精神病史的个体中，异维 A 酸后出现躁狂发作的这种情况具有重要意义。
