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提取物减轻雄性大鼠重铬酸钾诱导的睾丸退化：来自Nrf2及其靶基因信号通路的见解

extract mitigates potassium dichromate-induced testicular degeneration in male rats: Insights from the Nrf2 and its target genes signaling pathway.

作者信息

Nagy Ahmed M, Abdelhameed Mohamed F, Rihan Shaimaa, Diab Kawthar A, El-Saied Mohamed, Mohamed Shereif S, El-Nattat Walid S, Hammam Abdel Mohsen M

机构信息

Department of Animal Reproduction &AI, Veterinary Research Institute, National Research Centre, Cairo, Egypt.

Pharmacology Department, Medical research and clinical studies institute, National Research Centre, Cairo, Egypt.

出版信息

Toxicol Rep. 2024 Jul 24;13:101700. doi: 10.1016/j.toxrep.2024.101700. eCollection 2024 Dec.

DOI:10.1016/j.toxrep.2024.101700
PMID:39165924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11334654/
Abstract

This study aimed to investigate the protective effects of Rosemary ethanol extract (ROEE) on testicular damage induced by potassium Dichromate (PDC) in male rats regarding the signaling pathway of Nrf2 and its target genes and proteins. A total of 28 male rats were divided into four groups: control, PDC only (15 mg/kg b.w. orally), PDC + low dose ROEE (220 mg/kg b.w.), and PDC + high dose ROEE (440 mg/kg b.w.). After 28 days of consecutive treatment, the rats were sacrificed for histological, immunohistochemistry, and biochemical analyses. The results revealed that the ROEE treatment up-regulated the Nrf2 and its target genes (NQO1, HO-1) mRNA expressions compared to the PDC group. correspondingly, the protein levels of GCLM, GSH, SOD, and catalase were significantly increased in the ROEE-treated animals compared to the PDC-treated animals. Furthermore, ROEE administration led to increased serum levels of testosterone (T4) and decreased levels of estrogen (E2) compared to the PDC group. Semen analysis and histopathology demonstrated that ROEE administration significantly improved spermatological impairment caused by PDC. The immunoexpression of cytoplasmic HSP-90 was reduced in the ROEE-treated groups, while the expression of androgen receptor (AR) was markedly improved. ROEE exhibited protective effects against PDC-induced testicular damage, likely due to its antioxidant properties. However, further investigation is required to elucidate the underlying mechanisms of action.

摘要

本研究旨在探讨迷迭香乙醇提取物（ROEE）对重铬酸钾（PDC）诱导的雄性大鼠睾丸损伤的保护作用，涉及Nrf2信号通路及其靶基因和蛋白质。总共28只雄性大鼠被分为四组：对照组、仅PDC组（口服15mg/kg体重）、PDC +低剂量ROEE组（220mg/kg体重）和PDC +高剂量ROEE组（440mg/kg体重）。连续治疗28天后，处死大鼠进行组织学、免疫组织化学和生化分析。结果显示，与PDC组相比，ROEE治疗上调了Nrf2及其靶基因（NQO1、HO-1）的mRNA表达。相应地，与PDC处理的动物相比，ROEE处理的动物中GCLM、GSH、SOD和过氧化氢酶的蛋白质水平显著增加。此外，与PDC组相比，ROEE给药导致血清睾酮（T4）水平升高，雌激素（E2）水平降低。精液分析和组织病理学表明，ROEE给药显著改善了PDC引起的精子学损伤。ROEE处理组中细胞质HSP-90的免疫表达降低，而雄激素受体（AR）的表达显著改善。ROEE对PDC诱导的睾丸损伤具有保护作用，可能归因于其抗氧化特性。然而，需要进一步研究以阐明其潜在的作用机制。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a53/11334654/15fc8f30b7b7/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a53/11334654/a64e14ff2836/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a53/11334654/8b2c7ec334cb/gr9.jpg
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