Bozok Ümmü Gülşen, Özcan Gülbahar Böyük, Cinar Fatma Uysal
Department of Physiology, Faculty of Medicine Ankara Medipol University Ankara Türkiye.
Department of Histology and Embryology Faculty of Medicine Ankara Medipol University Ankara Türkiye.
Food Sci Nutr. 2025 May 13;13(5):e70211. doi: 10.1002/fsn3.70211. eCollection 2025 May.
This study aimed to find out how hawthorn extract protects against damage caused by torsion/detorsion (T/D). In the study, four groups were formed, each consisting of eight rats: control, T/D, low-dose hawthorn extract (T/D + LD), and high-dose hawthorn extract (T/D + HD). The effect of testosterone hormone and oxidative stress parameters of total antioxidant level (TAS), total oxidant level (TOS), as well as oxidative stress index (OSI) were evaluated. We examined the histopathological effects of the hawthorn extract. Additionally, sperm count and motility were analyzed. The analyses were conducted using the IBM SPSS v22 program, and a -value of less than 0.05 was deemed statistically significant. Testosterone, TAS, TOS, and OSI parameters show statistical differences between the groups ( = 0.014, = 0.009, = 0.021, = 0.004, respectively). Group differences in testicular volume are statistically significant ( = 0.001). The sperm count exhibits a statistically significant difference between the groups ( = 0.00). Sperm motility was affected only by groups at a statistically significant level ( = 0.00). Histopathologically, tissue damage decreased in the hawthorn extract groups compared to the T/D groups. Hawthorn extract has the potential to alleviate T/D-induced damage by reducing oxidative stress and protecting testicular tissue. The findings suggest that hawthorn extract may have therapeutic potential in mitigating oxidative damage caused by testicular torsion and providing sustained protective effects. Longer-term studies should explore the effects of hawthorn extract in greater detail, as these findings indicate that it may be a promising treatment option for acute testicular injury.
本研究旨在探究山楂提取物如何预防扭转/去扭转（T/D）造成的损伤。在该研究中，将大鼠分为四组，每组八只：对照组、T/D组、低剂量山楂提取物组（T/D + LD）和高剂量山楂提取物组（T/D + HD）。评估了睾酮激素以及总抗氧化水平（TAS）、总氧化水平（TOS）和氧化应激指数（OSI）等氧化应激参数的影响。我们检查了山楂提取物的组织病理学效应。此外，还分析了精子数量和活力。分析使用IBM SPSS v22程序进行，P值小于0.05被认为具有统计学意义。睾酮、TAS、TOS和OSI参数在各组之间显示出统计学差异（分别为P = 0.014、P = 0.009、P = 0.021、P = 0.004）。睾丸体积的组间差异具有统计学意义（P = 0.001）。精子数量在各组之间存在统计学显著差异（P = 0.00）。精子活力仅在具有统计学显著水平的组间受到影响（P = 0.00）。在组织病理学上，与T/D组相比，山楂提取物组的组织损伤有所减轻。山楂提取物有可能通过降低氧化应激和保护睾丸组织来减轻T/D诱导的损伤。研究结果表明，山楂提取物在减轻睾丸扭转引起的氧化损伤和提供持续保护作用方面可能具有治疗潜力。由于这些发现表明山楂提取物可能是急性睾丸损伤的一种有前景的治疗选择，因此长期研究应更详细地探索其效果。
