Zhao Lu, Pang Mengmeng, Fu Zhenyue, Wu Huaqin, Song Qingqiao
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, 5 Beixiange, Xicheng District, Beijing, 100053, China.
Beijing University of Chinese Medicine, Beijing, China.
Heliyon. 2024 Aug 2;10(15):e35299. doi: 10.1016/j.heliyon.2024.e35299. eCollection 2024 Aug 15.
Lipophagy is defined as the autophagic degradation of lipid droplets. It is a selective autophagy process that can continuously circulate and redistribute metabolites to maintain the body's energy balance. Over the last ten years, there has been a significant increase in the amount of literature on lipophagy, making it more challenging to track the field's advancement using conventional techniques. The data from the lipophagy literature published in the last ten years was converted into visual representations with the use of bibliometric tools. An increasing number of countries and institutions are delving further into lipophagy research with the support of visualization technologies. The five main illnesses of cancer, atherosclerosis, fatty liver, hyperlipidemia, and neurodegenerative diseases have become study opportunities, as have the mechanisms of macroautophagy, microautophagy, and chaperone-mediated autophagy.
脂质自噬被定义为脂滴的自噬性降解。它是一个选择性自噬过程,能够持续循环和重新分配代谢产物以维持身体的能量平衡。在过去十年中,关于脂质自噬的文献数量显著增加,这使得使用传统技术追踪该领域的进展变得更具挑战性。利用文献计量工具将过去十年发表的脂质自噬文献数据转化为可视化呈现。在可视化技术的支持下,越来越多的国家和机构正在深入开展脂质自噬研究。癌症、动脉粥样硬化、脂肪肝、高脂血症和神经退行性疾病这五种主要疾病已成为研究对象,巨自噬、微自噬和伴侣介导的自噬机制也同样如此。