Department of Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Department of Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Braz J Med Biol Res. 2024 Aug 19;57:e13809. doi: 10.1590/1414-431X2024e13809. eCollection 2024.
Small nucleolar RNAs (snoRNAs) have robust potential functions and therapeutic value in breast cancer. Herein, we investigated the role SNORA5A in breast cancer. Samples from The Cancer Genome Atlas (TCGA) were reviewed. The transcription matrix and clinical information were analyzed using R software and validated in clinical tissue samples. SNORA5A was significantly down-regulated in breast cancer, and high expression of SNORA5A correlated with a favorable prognosis. High expression of SNORA5A induced a high concentration of tumor-associated macrophages M1 and a low concentration of tumor-associated macrophages M2. Moreover, SNORA5A were clustered in terms related to cancer and immune functions. Possible downstream molecules of SNORA5A were identified, among which TRAF3IP3 was positively correlated with M1 and negatively correlated with M2. The function of TRAF3IP3 in tumor inhibition and its relationship with macrophages in clinical tissue samples were in accordance with bioinformatics analysis results. SNORA5A could regulate macrophage phenotypes through TRAF3IP3 and serves as a potential prognostic marker for breast cancer patients.
小核仁 RNA（snoRNAs）在乳腺癌中具有强大的潜在功能和治疗价值。在此，我们研究了 SNORA5A 在乳腺癌中的作用。我们对癌症基因组图谱（TCGA）中的样本进行了回顾。使用 R 软件分析转录矩阵和临床信息，并在临床组织样本中进行了验证。SNORA5A 在乳腺癌中显著下调，且 SNORA5A 高表达与预后良好相关。SNORA5A 高表达诱导肿瘤相关巨噬细胞 M1 浓度升高和肿瘤相关巨噬细胞 M2 浓度降低。此外，SNORA5A 聚类与癌症和免疫功能相关。鉴定到 SNORA5A 的可能下游分子，其中 TRAF3IP3 与 M1 呈正相关，与 M2 呈负相关。TRAF3IP3 在肿瘤抑制中的功能及其在临床组织样本中与巨噬细胞的关系与生物信息学分析结果一致。SNORA5A 可以通过 TRAF3IP3 调节巨噬细胞表型，是乳腺癌患者潜在的预后标志物。
