State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
College of Chemistry and Materials Science, Hunan Agricultural University, Changsha 410128, China.
Nano Lett. 2024 Sep 4;24(35):11002-11011. doi: 10.1021/acs.nanolett.4c03078. Epub 2024 Aug 21.
Early stage hepatocellular carcinoma (HCC) presents a formidable challenge in clinical settings due to its asymptomatic progression and the limitations of current imaging techniques in detecting micro-HCC lesions. Addressing this critical issue, we introduce a novel ultrathin gadolinium-oxide (Gd-oxide) nanosheet-based platform with heightened sensitivity for high-field MRI and as a therapeutic agent for HCC. Synthesized via a digestive ripening process, these Gd-oxide nanosheets exhibit an exceptional acid-responsive profile. The integration of the ultrathin Gd-oxide with an acid-responsive polymer creates an ultrasensitive high-field MRI probe, enabling the visualization of submillimeter-sized tumors with superior sensitivity. Our research underscores the ultrasensitive probe's efficacy in the treatment of orthotopic HCC. Notably, the ultrasensitive probe functions dually as a companion diagnostic tool, facilitating simultaneous imaging and therapy with real-time treatment monitoring capabilities. In conclusion, this study showcases an innovative companion diagnostic tool that holds promise for the early detection and effective treatment of micro-HCC.
早期肝细胞癌 (HCC) 在临床环境中构成了巨大的挑战，因为其无症状进展以及当前成像技术在检测微小 HCC 病变方面的局限性。为了解决这个关键问题，我们引入了一种新型的超薄氧化钆 (Gd-oxide) 纳米片平台，该平台在高场 MRI 中具有更高的灵敏度，并可用作 HCC 的治疗剂。通过消化成熟过程合成的这些 Gd-oxide 纳米片具有出色的酸响应特性。超薄 Gd-oxide 与酸响应聚合物的结合创造了一种超灵敏的高场 MRI 探针，能够以更高的灵敏度可视化亚毫米大小的肿瘤。我们的研究强调了超灵敏探针在治疗原位 HCC 中的功效。值得注意的是，该超灵敏探针具有双重功能，既是一种伴随诊断工具，又能同时进行成像和治疗，并具有实时治疗监测能力。总之，这项研究展示了一种创新的伴随诊断工具，有望用于早期发现和有效治疗微小 HCC。
