Pan Xingtong, Hu Menglong, Wu Likun, Wei Erfan, Zhu Qiyue, Lv Letian, Xv Xiuyun, Dong Xinyi, Liu Hao, Liu Yunsong
Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Adv Sci (Weinh). 2025 May;12(20):e2501722. doi: 10.1002/advs.202501722. Epub 2025 Apr 25.
The potential applications of rare earth elements (REEs) in biomedical fields have been intensively investigated. Numerous studies have shown that doping biomaterials with REEs can enhance their properties. Gadolinium (Gd) is a biocompatible REE that holds promise in biomedical applications. This review examines the use of Gd-doped biomaterials in osteogenic, antimicrobial, anticancer applications, and in bioimaging and bioprobes, as reported in the literature until December 2024. The included studies demonstrate that Gd-containing biomaterials promote osteogenesis, enhance antimicrobial properties, and perform well in anticancer applications and bioimaging. Taken together, they point to the considerable potential of Gd-doped biomaterials and thus to avenues for future research.
稀土元素（REEs）在生物医学领域的潜在应用已得到深入研究。大量研究表明，在生物材料中掺杂稀土元素可以增强其性能。钆（Gd）是一种具有生物相容性的稀土元素，在生物医学应用中具有前景。本综述考察了截至2024年12月文献报道中钆掺杂生物材料在成骨、抗菌、抗癌应用以及生物成像和生物探针方面的应用。纳入的研究表明，含钆生物材料可促进成骨、增强抗菌性能，并在抗癌应用和生物成像方面表现良好。综合来看，它们指出了钆掺杂生物材料的巨大潜力，从而也指明了未来的研究方向。
