Dermatology, Venereology and Andrology, Faculty of Medicine, South Valley University, Qena, Egypt.
Tropical medicine and gastroenterology Department, Faculty of Medicine, South Valley University, Qena, Egypt.
Skin Res Technol. 2024 Aug;30(8):e70005. doi: 10.1111/srt.70005.
Psoriasis is a prevalent inflammatory skin condition that can be recognized by silvery-white scales on plaques and erythematous papules, despite the fact that psoriasis appears to have multiple causes. Helicobacter pylori (H. pylori) has been investigated recently as a potential infectious etiological component.
The objective of the study was to evaluate the prevalence of H. pylori infection in psoriatic patients compared to that of healthy controls and determine whether the degree of psoriasis and H. pylori infection were related.
The dermatology, venerology, and andrology department at South Valley University Outpatient Clinic carried out this cross-sectional study. Psoriatic patients of both sexes and ages were included. In addition to the control group, H. Pylori antigen was measured from psoriatic and control groups by using H. pylori stool antigen-enzyme linked immunosorbent assay (HpSA-ELISA), a test for H. pylori stool antigen. More than 20 ng/mL of antigen proved positive, or less than 15 ng/mL proved negative.
There was a significant difference between psoriatic patients and control regarding H. pylori infection (p = 0.046): (30.66%) positive in controls, (45.33%) positive in psoriatic patients. Both groups were matched for age (p = 0.908), that is, the mean age of psoriatic patients was 37.44 ± 15.79 years, and the control group was 37.15 ± 15.15 years. Twenty-five psoriatic patients in each group: mild, moderate, and severe psoriasis according to the Psoriasis Area Severity Index (PASI) score. No significant correlation between H. pylori infection and PASI, age, or duration of illness in psoriatic patients.
Patients with psoriasis had greater rates of H. pylori infection but didn't affect the severity of psoriasis.
银屑病是一种常见的炎症性皮肤病，其特征是斑块上有银白色鳞屑和红斑丘疹，尽管银屑病似乎有多种病因。最近，幽门螺杆菌（H. pylori）已被研究为一种潜在的感染病因。
本研究旨在评估银屑病患者中 H. pylori 感染的流行率，并与健康对照组进行比较，同时确定银屑病的严重程度与 H. pylori 感染之间的关系。
这项横断面研究在南河谷大学门诊皮肤科、性病科和男科进行。纳入了男女和各年龄段的银屑病患者。除了对照组外，还通过 H. pylori 粪便抗原酶联免疫吸附试验（HpSA-ELISA）检测银屑病组和对照组的 H. pylori 抗原，该试验用于检测 H. pylori 粪便抗原。抗原大于 20ng/mL 为阳性，小于 15ng/mL 为阴性。
银屑病患者与对照组在 H. pylori 感染方面存在显著差异（p=0.046）：对照组中阳性率为 30.66%，银屑病组中阳性率为 45.33%。两组在年龄方面相匹配（p=0.908），即银屑病患者的平均年龄为 37.44±15.79 岁，对照组为 37.15±15.15 岁。每组有 25 名银屑病患者，根据银屑病面积严重程度指数（PASI）评分分为轻度、中度和重度银屑病。在银屑病患者中，H. pylori 感染与 PASI、年龄或病程之间无显著相关性。
银屑病患者 H. pylori 感染率较高，但 H. pylori 感染不会影响银屑病的严重程度。
