Campanati Anna, Ganzetti Giulia, Martina Emanuela, Giannoni Melania, Gesuita Rosaria, Bendia Emanuele, Giuliodori Katia, Sandroni Lucia, Offidani Annamaria
Dermatological Unit, Department of Clinical and Moleciular Sciences, Polytechnic Marche University, Ancona, Italy.
Int J Dermatol. 2015;54(5):e109-14. doi: 10.1111/ijd.12798. Epub 2015 Mar 23.
Data from the literature concerning the role of Helicobacter pylori (H. pylori) infection in psoriasis are still conflicting. This study was carried out to evaluate prevalence of H. pylori in patients with mild to severe psoriasis, correlation between H. pylori infection and severity of psoriasis, and effect of H. pylori eradication on the clinical course of psoriasis.
Two hundred and ten patients with psoriasis and 150 healthy controls were screened for H. pylori through [(13) C] urea breath test at baseline (T0). All patients with psoriasis received standardized phototherapy treatment, and those infected by H. pylori were also treated with a 1-week triple therapy, then they were all re-evaluated four weeks later at the end of therapy (T5).
The prevalence of H. pylori was not higher in psoriasis than in the control group (20.27 vs. 22%; P > 0.05). Patients infected by H. pylori showed more severe psoriasis than uninfected patients (psoriasis area and severity index score 17.9 ± 7.1 vs. 13.7 ± 6.9; P = 0.04), and patients who received successful eradication of H. pylori infection showed a greater improvement of psoriasis than the others (psoriasis area and severity index score at T5 in patients infected by H. pylori was 8.36 ± 3.76, in uninfected patients was 10.85 ± 3.49; P = 0.006).
Patients with mild to severe psoriasis do not show a greater prevalence of H. pylori infection; however, H. pylori seems able to affect the clinical severity of psoriasis.
关于幽门螺杆菌（H. pylori）感染在银屑病中作用的文献数据仍存在矛盾。本研究旨在评估轻至重度银屑病患者中幽门螺杆菌的患病率、幽门螺杆菌感染与银屑病严重程度之间的相关性，以及根除幽门螺杆菌对银屑病临床病程的影响。
在基线（T0）时，通过[（13）C]尿素呼气试验对210例银屑病患者和150例健康对照者进行幽门螺杆菌筛查。所有银屑病患者均接受标准化光疗，幽门螺杆菌感染患者还接受为期1周的三联疗法治疗，然后在治疗结束4周后（T5）对所有患者进行重新评估。
银屑病患者中幽门螺杆菌的患病率并不高于对照组（20.27%对22%；P>0.05）。幽门螺杆菌感染患者的银屑病比未感染患者更严重（银屑病面积和严重程度指数评分17.9±7.1对13.7±6.9；P=0.04），成功根除幽门螺杆菌感染的患者银屑病改善程度比其他患者更大（幽门螺杆菌感染患者T5时的银屑病面积和严重程度指数评分为8.36±3.76，未感染患者为10.85±3.49；P=0.006）。
轻至重度银屑病患者幽门螺杆菌感染率并未更高；然而，幽门螺杆菌似乎能够影响银屑病的临床严重程度。
