MacGibeny Margaret A, Adjei Susuana, Pyle Hunter, Bunick Christopher G, Ghannoum Mahmoud, Grada Ayman, Harris-Tryon Tamia, Tyring Stephen K, Kong Heidi H
Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
Department of Dermatology, Lake Granbury Medical Center, Dallas, TX, USA.
J Am Acad Dermatol. 2024 Aug 19. doi: 10.1016/j.jaad.2024.07.1498.
Human skin is home to a myriad of microorganisms, including bacteria, viruses, fungi, and mites, many of which are considered commensal microbes that aid in maintaining the overall homeostasis or steady-state condition of the skin and contribute to skin health. Our understanding of the complexities of the skin's interaction with its microorganisms is evolving. This knowledge is based primarily on in vitro and animal studies, and more work is needed to understand how this knowledge relates to humans. Here, we introduce the concept of the skin microbiome and discuss skin microbial ecology, some intrinsic factors with potential influence on the human skin microbiome, and possible microbiome-host interactions. The second article of this two-part CME series describes how microbiome alterations may be associated with skin disease, how medications can affect the microbiome, and what microbiome-based therapies are under investigation.
人类皮肤是无数微生物的家园，包括细菌、病毒、真菌和螨虫，其中许多被认为是共生微生物，有助于维持皮肤的整体动态平衡或稳态，并对皮肤健康有益。我们对皮肤与其微生物相互作用的复杂性的理解正在不断发展。这一知识主要基于体外研究和动物研究，还需要更多的工作来了解这些知识如何与人类相关。在这里，我们介绍皮肤微生物组的概念，并讨论皮肤微生物生态学、一些可能对人类皮肤微生物组产生影响的内在因素，以及微生物组与宿主之间可能的相互作用。这个两部分的继续医学教育系列的第二篇文章描述了微生物组改变如何与皮肤疾病相关、药物如何影响微生物组，以及正在研究哪些基于微生物组的疗法。
