Department of Radiology, University of Colorado, Aurora, CO.
Department of Radiology, University of Colorado, Aurora, CO; Division of Pediatric Radiology, Children's Hospital Colorado, University of Colorado, Aurora, CO.
Tech Vasc Interv Radiol. 2024 Jun;27(2):100957. doi: 10.1016/j.tvir.2024.100957. Epub 2024 Jun 14.
This review explores the clinical presentation of lower extremity DVT and pulmonary embolism (PE), treatment strategies, and outcomes for venous thromboembolism (VTE) in the pediatric population. Traditional therapy for pediatric VTE was anticoagulation alone with thrombolysis and surgery reserved only in life or limb-threatening cases. Catheter-directed thrombolysis (CDT), pharmacomechanical thrombectomy (PMT) and mechanical thrombectomy (MT) have emerged as effective and safe treatment options for VTE management. Although most data are from adult studies, early pediatric studies suggest that these interventional procedures can be effective in children. The significant clinical impact of post-thrombotic syndrome (PTS) is also discussed, as PTS can lead to lifelong physical symptoms and psychosocial damage.
这篇综述探讨了下肢深静脉血栓形成（DVT）和肺栓塞（PE）的临床表现、儿科人群静脉血栓栓塞症（VTE）的治疗策略和结局。儿科 VTE 的传统治疗方法是单独抗凝，溶栓和手术仅保留在危及生命或肢体的情况下。导管溶栓（CDT）、机械血栓切除术（PMT）和机械血栓切除术（MT）已成为 VTE 管理的有效且安全的治疗选择。尽管大多数数据来自成人研究，但早期儿科研究表明，这些介入性手术在儿童中也可能有效。血栓后综合征（PTS）的显著临床影响也在讨论中，因为 PTS 可导致终生的身体症状和社会心理损害。
