Department of Dermatology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Guangzhou Mylike Medical Cosmetic Hospital, Guangzhou, Guangdong, China.
Lasers Med Sci. 2024 Aug 22;39(1):221. doi: 10.1007/s10103-024-04048-5.
Non-insulated microneedle radiofrequency (NIMNRF) is a method of promoting dermal collagen shrinking and remodeling with minor injury reducing wrinkles. We conducted a 3-years retrospective observation on wrinkles of facial photoaging subjects treated with NIMNRF in Chinese subjects to demonstrate the efficacy and side effects. Chinese subjects clinically diagnosed as facial photoaging treated with MNRF in the Laser Center of The First Hospital of China Medical University and Guangzhou Mylike Medical Cosmetic Hospital from Jan 1, 2018 to Dec 31, 2021 were enrolled in this study. Inclusion criteria included. Each subject was treated with NIMNRF for 1-3 sessions, with a 3-month interval. At baseline and 3 months after each treatment, a Wrinkle Assessment Scale (WAS) was used to score the wrinkles in 10 areas. The total WAS score and WAS improvement rate was assessed at each time point. A total of 96 subjects, aged 25-65 years old, received at least one session of NIMNRF were enrolled. 63, 24, 9 of them received 1, 2 or 3 sessions, respectively. The total WAS score decreased from 14.65 ± 9.20 to 11.51 ± 8.70 after Session 1, from 15.92 ± 9.48 to 12.17 ± 8.83 after Session 2 and from 17.56 ± 6.99 to 11.11 ± 7.13 after Session 3 (P < 0.01). The WAS improvement rate was 25.61%, 30.69% and 39.82% after 1, 2, 3 sessions, respectively. As for subjects in different age groups, the improvement rate decreased with age, from 39.13% in 25-30 years old group to 16.39% in over 60 years old group after Session 1 (P < 0.05). Better efficacy and less sessions of treatments were conducted in younger subjects. NIMNRF can be used in the treatment of facial wrinkles in photoaging subjects, especially in youngster as better efficacy.
非绝缘微针射频（NIMNRF）是一种通过微损伤促进真皮胶原蛋白收缩和重塑以减少皱纹的方法。我们对在中国医科大学第一医院激光中心和广州美莱医疗美容医院接受 NIMNRF 治疗的面部光老化受试者的皱纹进行了为期 3 年的回顾性观察，以证明其疗效和副作用。
本研究纳入了 2018 年 1 月 1 日至 2021 年 12 月 31 日期间在中国医科大学第一医院激光中心和广州美莱医疗美容医院接受 MNRF 治疗的临床诊断为面部光老化的中国受试者。纳入标准包括：每个受试者接受 NIMNRF 治疗 1-3 次，间隔 3 个月。在基线和每次治疗后 3 个月，使用皱纹评估量表（WAS）对 10 个区域的皱纹进行评分。在每个时间点评估总 WAS 评分和 WAS 改善率。
共有 96 名年龄在 25-65 岁之间的受试者至少接受了一次 NIMNRF 治疗，其中 63、24 和 9 名受试者分别接受了 1、2 或 3 次治疗。总 WAS 评分从第 1 次治疗后的 14.65±9.20 降至 11.51±8.70，从第 2 次治疗后的 15.92±9.48 降至 12.17±8.83，从第 3 次治疗后的 17.56±6.99 降至 11.11±7.13（P<0.01）。第 1、2、3 次治疗后的 WAS 改善率分别为 25.61%、30.69%和 39.82%。对于不同年龄组的受试者，改善率随年龄的增长而降低，从第 1 次治疗后 25-30 岁组的 39.13%降至 60 岁以上组的 16.39%（P<0.05）。年轻受试者的疗效更好，所需治疗次数更少。
NIMNRF 可用于治疗光老化受试者的面部皱纹，尤其是年轻人，疗效更好。
