Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.
Unit of Dermatology, University of Rome, Tor Vergata, Rome, Italy.
Photobiomodul Photomed Laser Surg. 2021 Feb;39(2):113-117. doi: 10.1089/photob.2020.4876. Epub 2021 Jan 15.
This randomized controlled trial aims to verify the efficacy of a combined fractional CO laser and rhodamine-intense pulsed-light (r-IPL) protocol in the photoaging therapy. Skin aging is related to multiple environmental and genetic factors that give rise to different manifestations. In recent years many techniques have been proposed for the rejuvenation of the skin of the face such as ablative and nonablative procedures. Combination of laser or light sources with different wavelengths represents a safe and effective treatment method. r-IPL is a new pulsed-light technique capable to generate wavelengths varying from 550 to 650 nm proposed in nonablative photorejuvenation with a good efficacy and safety profile. Twenty-two patients (skin phototypes II-III, aged 46-67 years) were randomly allocated into two groups: group A was treated only with a therapeutic standard dose of the fractional CO laser, whereas group B was treated with a combined therapy of r-IPL and fractional CO laser. All patients were treated up to three times at a 2-month interval. Efficacy of the procedures was assessed thanks to the Fitzpatrick Wrinkle Severity Scale (scores 1-9) before treatment and at a 4-month follow-up from the last treatment. Patients treated with the combination of r-IPL and fractional CO laser showed better results in terms of wrinkle reduction according to the Fitzpatrick Wrinkle Severity score (2.82 ± 0.87 vs. 3.09 ± 1.14), with a statistically significant reduction in healing times (7.82 ± 0.75 vs. 13.82 ± 1.94 days, ≤ 0.001) and duration of post-treatment erythema (3.55 ± 0.93 vs. 8.18 ± 1.47 days, ≤ 0.001). Patient satisfaction was higher after combined fractional CO laser and r-IPL treatment. Our data suggest that combined use of fractional CO laser and r-IPL may lead to excellent results in terms of skin rejuvenation with a simple post-treatment management and an optimal tolerability.
这项随机对照试验旨在验证联合分段 CO2 激光和罗丹明强脉冲光（r-IPL）方案在光老化治疗中的疗效。皮肤老化与多种环境和遗传因素有关，这些因素导致了不同的表现。近年来，许多技术已被提议用于面部皮肤的年轻化，如消融和非消融程序。不同波长的激光或光源的组合代表了一种安全有效的治疗方法。r-IPL 是一种新的脉冲光技术，能够产生 550 至 650nm 的波长，在非消融光嫩肤中具有良好的疗效和安全性。22 名患者（皮肤光型 II-III，年龄 46-67 岁）被随机分为两组：A 组仅接受标准治疗剂量的分段 CO2 激光治疗，而 B 组接受 r-IPL 和分段 CO2 激光联合治疗。所有患者在 2 个月的间隔内接受了三次治疗。在治疗前和最后一次治疗后 4 个月，采用 Fitzpatrick 皱纹严重程度评分（评分 1-9）评估治疗效果。接受 r-IPL 和分段 CO2 激光联合治疗的患者在皱纹减少方面的疗效根据 Fitzpatrick 皱纹严重程度评分显示出更好的结果（2.82±0.87 与 3.09±1.14），愈合时间（7.82±0.75 与 13.82±1.94 天， ≤ 0.001）和治疗后红斑持续时间（3.55±0.93 与 8.18±1.47 天， ≤ 0.001）有统计学意义减少。联合使用分段 CO2 激光和 r-IPL 治疗后的患者满意度更高。我们的数据表明，分段 CO2 激光和 r-IPL 的联合使用可能会导致皮肤年轻化的出色效果，具有简单的治疗后管理和最佳的耐受性。
