NOS3-rs1799983 和 NOS3-rs2070744 SNP 在 COVID-19 后并发症之一的缺血性坏死发病中的作用。
The role of NOS3-rs1799983 and NOS3- rs2070744 SNP in occurrence of avascular necrosis as a post COVID-19 complication.
机构信息
Department of Chemistry, Biochemistry Division, Faculty of Science, Menoufia University, Menoufia, Egypt.
Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
出版信息
BMC Med Genomics. 2024 Aug 21;17(1):217. doi: 10.1186/s12920-024-01928-1.
Avascular necrosis (AVN) is a debilitating condition characterized by bone tissue death due to inadequate blood supply, leading to joint dysfunction and collapse. This study investigates the potential association between AVN and COVID-19, focusing on genetic factors such as NOS3 polymorphisms. A total of 180 individuals were included, comprising 120 COVID-19 patients and 60 healthy controls. Clinical, haematological, biochemical, and genetic parameters were assessed. Results revealed significant differences in respiratory and heart rates, haematological counts, and biochemical markers between AVN and control groups. Genetic analysis showed a higher prevalence of the TG genotype and G allele in NOS3 rs1799983 polymorphism among AVN patients. Additionally, NOS3 rs2070744 polymorphism correlated with various clinical parameters, including blood pressure, heart rate, and haematological indices. This study highlights the potential role of genetic factors in predisposing individuals to AVN following COVID-19 infection.
股骨头坏死（AVN）是一种因供血不足导致骨组织坏死的使人虚弱的疾病，可导致关节功能障碍和塌陷。本研究探讨了 AVN 与 COVID-19 之间的潜在关联，重点关注 NOS3 多态性等遗传因素。共纳入 180 名个体，包括 120 名 COVID-19 患者和 60 名健康对照。评估了临床、血液学、生物化学和遗传参数。结果显示，AVN 组和对照组在呼吸和心率、血液学计数和生化标志物方面存在显著差异。遗传分析显示，NOS3 rs1799983 多态性中的 TG 基因型和 G 等位基因在 AVN 患者中更为常见。此外，NOS3 rs2070744 多态性与血压、心率和血液学指标等各种临床参数相关。本研究强调了遗传因素在 COVID-19 感染后使个体易患 AVN 方面的潜在作用。
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