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减重手术治疗高尿酸血症的研究进展。

Research progress on bariatric surgery for hyperuricemia.

机构信息

Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan Province, China.

Institute of Hepatobiliary Pancreatic Intestinal Diseases, North Sichuan Medical College, Nanchong, 637000, Sichuan Province, China.

出版信息

BMC Surg. 2024 Aug 21;24(1):235. doi: 10.1186/s12893-024-02525-w.

Abstract

Hyperuricemia is closely linked to obesity. As lifestyles and dietary patterns evolve, the prevalence of hyperuricemia has been on the rise. Bariatric surgery, an efficacious intervention for morbid obesity and its associated metabolic disorders, not only manages the weight of patients with severe obesity but also exerts beneficial therapeutic effects on hyperuricemia and gout. Moreover, it demonstrates substantial efficacy against other obesity-related metabolic conditions. However, the dramatic fluctuations in serum uric acid levels and acute gouty attacks in the immediate postoperative period are issues that should not be overlooked, and effective preventative strategies for some related adverse complications are still underexplored. This review discusses and reviews the advancements in the treatment of obese patients with hyperuricemia through bariatric surgery. By reviewing pertinent literature, it summarizes the short-term and long-term therapeutic outcomes of bariatric surgery for hyperuricemia, as well as common adverse reactions. Furthermore, by discussing preoperative and postoperative interventional measures and influential factors, this review aims to provide novel perspectives for the clinical management of hyperuricemia and offer insights for the prevention of related complications.

摘要

高尿酸血症与肥胖密切相关。随着生活方式和饮食模式的演变,高尿酸血症的患病率呈上升趋势。减重手术是治疗病态肥胖及其相关代谢紊乱的有效方法,不仅可以控制重度肥胖患者的体重,而且对高尿酸血症和痛风也有有益的治疗作用。此外,它对其他肥胖相关的代谢疾病也有显著疗效。然而,术后短期内血清尿酸水平的剧烈波动和急性痛风发作是不容忽视的问题,一些相关不良并发症的有效预防策略仍有待探索。本综述通过讨论和回顾减重手术治疗肥胖伴高尿酸血症的进展,通过复习相关文献,总结了减重手术治疗高尿酸血症的短期和长期疗效以及常见的不良反应。此外,通过讨论术前和术后的干预措施和影响因素,为高尿酸血症的临床管理提供新的视角,并为相关并发症的预防提供思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3266/11337558/b19377a45c7a/12893_2024_2525_Fig1_HTML.jpg

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