Vafa Leila, Amini Masoud, Kamran Hooman, Aghakhani Ladan, Hosseini Seyed Vahid, Mohammadi Zahra, Haghighat Neda
Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.
Clin Nutr Res. 2023 Jan 25;12(1):21-28. doi: 10.7762/cnr.2023.12.1.21. eCollection 2023 Jan.
Studies indicate an association between hyperuricemia (HUA) and metabolic syndrome risk factors. On the other hand, obesity is a major modifiable and independent risk factor for HUA and gout. However, evidence concerning the effects of bariatric surgery on serum uric acid levels is limited and not completely clarified. This retrospective study was carried out with 41 patients who underwent sleeve gastrectomy (n = 26) and Roux-en-Y gastric bypass (n = 15) from September 2019 to October 2021. Anthropometric, clinical, and biochemical data, including uric acid blood urea nitrogen and creatinine fasting blood sugar (FBS), serum triglyceride (TG), and serum cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), were measured preoperatively and postoperative 3, 6 and 12 months. From baseline to 6 and 12 months, bariatric surgery resulted in a significant decrease in serum uric acid of patients with severe obesity (p < 0.001). The decreases in serum FBS, TG, and cholesterol of patients were significant during 6 and 12 months of follow-up (p < 0.05). However, the HDL increase of patients was not statistically significant in 6 and 12 months (p > 0.05). Besides, although patients' serum level of LDL decreased significantly during the 6 months of follow-up (p = 0.007), it was not significant after 12 months (p = 0.092). Bariatric surgery significantly reduces serum uric acid levels. Therefore, it may be an effective supplementary therapy for lowering serum uric acid concentrations in morbidly obese patients.
研究表明高尿酸血症（HUA）与代谢综合征风险因素之间存在关联。另一方面，肥胖是HUA和痛风的一个主要可改变的独立风险因素。然而，关于减肥手术对血清尿酸水平影响的证据有限且尚未完全阐明。本回顾性研究对2019年9月至2021年10月期间接受袖状胃切除术（n = 26）和Roux-en-Y胃旁路术（n = 15）的41例患者进行。术前及术后3、6和12个月测量人体测量学、临床和生化数据，包括尿酸、血尿素氮、肌酐、空腹血糖（FBS）、血清甘油三酯（TG）、血清胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）。从基线到6个月和12个月，减肥手术使重度肥胖患者的血清尿酸显著降低（p < 0.001）。在随访的6个月和12个月期间，患者的血清FBS、TG和胆固醇显著降低（p < 0.05）。然而，患者的HDL在6个月和12个月时升高无统计学意义（p > 0.05）。此外，虽然患者的血清LDL水平在随访的6个月期间显著降低（p = 0.007），但在12个月后无显著变化（p = 0.092）。减肥手术可显著降低血清尿酸水平。因此，它可能是降低病态肥胖患者血清尿酸浓度的一种有效辅助治疗方法。
