Medical School of Nantong University, Nantong, Jiangsu Province, China.
Department of Orthopedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
J Biomed Mater Res A. 2024 Dec;112(12):2358-2371. doi: 10.1002/jbm.a.37788. Epub 2024 Aug 21.
A severe disorder known as spinal cord damage causes both motor and sensory impairment in the limbs, significantly reducing the patients' quality of life. After a spinal cord injury, functional recovery and therapy have emerged as critical concerns. Hydrogel microspheres have garnered a lot of interest lately because of their enormous promise in the field of spinal cord injury rehabilitation. The material classification of hydrogel microspheres (natural and synthetic macromolecule polymers) and their synthesis methods are examined in this work. This work also covers the introduction of several kinds of hydrogel microspheres and their use as carriers in the realm of treating spinal cord injuries. Lastly, the study reviews the future prospects for hydrogel microspheres and highlights their limitations and problems. This paper can offer feasible ideas for researchers to advance the application of hydrogel microspheres in the field of spinal cord injury.
一种严重的疾病称为脊髓损伤，会导致四肢运动和感觉功能障碍，极大地降低了患者的生活质量。脊髓损伤后，功能恢复和治疗成为关键关注点。水凝胶微球因其在脊髓损伤康复领域的巨大潜力而受到广泛关注。本工作考察了水凝胶微球的材料分类（天然和合成高分子聚合物）及其合成方法。本工作还介绍了几种水凝胶微球及其在治疗脊髓损伤中的载体应用。最后，本文综述了水凝胶微球的未来前景，并强调了其局限性和问题。本文可为研究人员提供可行的思路，以推进水凝胶微球在脊髓损伤领域的应用。
