Zhao Yan, Aili Abudunaibi, Jia Zhiwei, Wen Tianlin, Muheremu Aikeremujiang
Department of Rehabilitative Medicine, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China.
Key Laboratory of Orthopaedic Regenerative Medicine, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China.
Bioengineering (Basel). 2025 Mar 28;12(4):347. doi: 10.3390/bioengineering12040347.
Because of the evolving nature of tissue engineering scaffolds in the treatment of spinal cord injury (SCI), the current study was carried out to evaluate the research productivity of tissue engineering scaffolds in the treatment of SCI.
Studies published from 2000 to 2025 were retrieved from the Web of Science core collection with topics of spinal cord injury and tissue engineering scaffolds. The data were analyzed and visualized using the VOSviewer network analysis software.
Among 1542 articles analyzed, annual publications surged from 2000 to 2019, stabilizing thereafter. The U.S., China, and Canada led in productivity, with Northwestern University and the journal being top contributors. Keyword analysis revealed research hotspots such as functional recovery, axonal regeneration, stem cells, and hydrogels. Notably, hydrogels embedded with genetically engineered cells emerged as a pivotal trend, reflecting a shift toward biomimetic and combinatorial therapies. Collaboration networks highlighted intensified partnerships between Chinese and North American institutions, signaling global interdisciplinary efforts.
This study provides the first bibliometric roadmap for tissue engineering scaffolds in SCI, identifying key trends, influential entities, and underexplored areas. The rise in hydrogels and international collaborations underscores opportunities for targeted research. These findings guide researchers in prioritizing high-impact journals, fostering partnerships, and advancing novel scaffold designs to bridge translational gaps in SCI treatment.
鉴于组织工程支架在脊髓损伤（SCI）治疗中的不断发展，开展本研究以评估组织工程支架在SCI治疗方面的研究产出。
从科学网核心合集检索2000年至2025年发表的主题为脊髓损伤和组织工程支架的研究。使用VOSviewer网络分析软件对数据进行分析和可视化处理。
在分析的1542篇文章中，年度发表量从2000年到2019年呈上升趋势，此后趋于稳定。美国、中国和加拿大在研究产出方面领先，西北大学和该期刊是主要贡献者。关键词分析揭示了功能恢复、轴突再生、干细胞和水凝胶等研究热点。值得注意的是，嵌入基因工程细胞的水凝胶成为一个关键趋势，反映了向仿生和联合治疗的转变。合作网络突出了中国和北美机构之间加强的伙伴关系，标志着全球跨学科的努力。
本研究为SCI中组织工程支架提供了首个文献计量路线图，确定了关键趋势、有影响力的实体和未充分探索的领域。水凝胶和国际合作的增加凸显了针对性研究的机会。这些发现指导研究人员优先选择高影响力期刊、促进伙伴关系，并推进新型支架设计以弥合SCI治疗中的转化差距。
