Masucci Marisa, Capucchio Maria Teresa, Buttitta Rosalinda, Colombino Elena, Mignacca Sebastian Alessandro
Department of Veterinary Sciences, University of Messina, Messina, Italy.
Department of Veterinary Sciences, University of Turin, Turin, Italy.
Vet Med (Praha). 2022 Jan 15;67(1):51-58. doi: 10.17221/8/2021-VETMED. eCollection 2022 Jan.
The clinical, electroencephalographic and neuro-pathological features of three cases (cases 1, 2 and 3) of congenital hydrocephalus in sheep were described. The observed neurological signs reflected damage in the telencephalon and brain stem. The electroencephalogram performed in case 1 and case 2 showed different patterns: symmetric and synchronous high-voltage slow-activity in case 1, and low-voltage slow-activity in case 2. By the post-mortem examination, in all the animals, dilatation of the ventricular system, especially of the lateral ventricles, associated with a glial reaction surrounding the dilated ventricles was observed. Only in case 3, a monolateral meningeal thickening at the left cerebellopontine angle seemed to be responsible for the obstructive hydrocephalus. In the other two brains (case 1 and 2), no potential anatomical cause for the hydrocephalus were detected, even if, in case 2, a compensatory form was not excluded due to the moderate hypoplasia of the cerebrum and the presence of the non-suppurative inflammation. The results of this work provide a contribution to the EEG characterisation in ovine hydrocephalus cases; nevertheless further multidisciplinary studies of a larger number of sheep could permit to better characterise the EEG pattern in ovine hydrocephalus cases.
描述了绵羊先天性脑积水3例（病例1、2和3）的临床、脑电图和神经病理学特征。观察到的神经学体征反映了端脑和脑干的损伤。病例1和病例2的脑电图表现出不同模式：病例1为对称且同步的高电压慢波活动，病例2为低电压慢波活动。通过尸检，在所有动物中均观察到脑室系统扩张，尤其是侧脑室扩张，并伴有围绕扩张脑室的胶质反应。仅在病例3中，左侧小脑脑桥角处的单侧脑膜增厚似乎是梗阻性脑积水的原因。在另外两个大脑（病例1和2）中，未检测到脑积水的潜在解剖学原因，即使在病例2中，由于大脑中度发育不全和存在非化脓性炎症，也不能排除代偿形式。这项工作的结果为绵羊脑积水病例的脑电图特征描述做出了贡献；然而，对更多绵羊进行进一步的多学科研究可能有助于更好地描述绵羊脑积水病例的脑电图模式。
