Lin Bin, Xu Meng, Chen Long-Long, Li Dong-Kan
Xiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China.
Front Med (Lausanne). 2024 Aug 7;11:1410607. doi: 10.3389/fmed.2024.1410607. eCollection 2024.
Glaucoma, a leading cause of global blindness, is characterized by optic nerve damage and visual field loss. Previous studies have suggested a potential association between glaucoma and anxiety disorders. However, the causal relationship between these two conditions remains unclear.
In this study, we conducted a Mendelian Randomization analysis to investigate the causal relationship between glaucoma and anxiety disorders. We sourced Genome-Wide Association Study (GWAS) datasets for glaucoma and anxiety with the largest sample sizes from the Integrative Epidemiology Unit OpenGWAS (IEU OpenGWAS) project website. Instrumental variables were selected based on specific criteria, and statistical analyses were performed using the R programming language.
After filtering and merging the datasets, a total of 60 Single Nucleotide Polymorphisms (SNPs) were obtained for analysis. Regression models were applied to assess the causal relationship between glaucoma and anxiety disorders. The results from all four methods indicated that glaucoma does not cause anxiety disorders ( > 0.05).
Through rigorous Mendelian Randomization analysis, our findings indicate that glaucoma is not a causative factor for anxiety, with minimal influence from confounding factors in this study. These findings enhance our understanding of the relationship between glaucoma and anxiety.
青光眼是全球失明的主要原因之一，其特征为视神经损伤和视野缺损。先前的研究表明青光眼与焦虑症之间可能存在关联。然而，这两种病症之间的因果关系仍不明确。
在本研究中，我们进行了孟德尔随机化分析，以探究青光眼与焦虑症之间的因果关系。我们从综合流行病学单位开放全基因组关联研究（IEU OpenGWAS）项目网站获取了样本量最大的青光眼和焦虑症全基因组关联研究（GWAS）数据集。根据特定标准选择工具变量，并使用R编程语言进行统计分析。
在对数据集进行筛选和合并后，共获得60个单核苷酸多态性（SNP）用于分析。应用回归模型评估青光眼与焦虑症之间的因果关系。所有四种方法的结果均表明青光眼不会导致焦虑症（>0.05）。
通过严格的孟德尔随机化分析，我们的研究结果表明青光眼不是焦虑症的致病因素，本研究中混杂因素的影响极小。这些发现增进了我们对青光眼与焦虑症之间关系的理解。
