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毛囊柱数量与斑秃病例严重程度及治疗反应之间的关联：一项回顾性研究。

The Association between Number of Follicular Stelae and Severity and Treatment Response of Alopecia Areata Cases: A Retrospective Study.

作者信息

Gencebay Güllü, Aşkin Özge, Aydin Övgü, Serdaroğlu Server

机构信息

Department of Dermatology, Şirnak State Hospital, Şirnak, Turkey.

Department of Dermatology, Istanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, Istanbul, Turkey.

出版信息

Int J Trichology. 2023 Sep-Oct;15(5):191-193. doi: 10.4103/ijt.ijt_76_21. Epub 2024 Jul 11.

DOI:10.4103/ijt.ijt_76_21
PMID:39170085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11335049/
Abstract

BACKGROUND

Alopecia areata (AA) is an autoimmune disease characterized by peribulbar lymphocytic infiltration, follicular miniaturization, catagen/telogen follicles, and increased follicular stelae (streamers) in skin biopsies.

OBJECTIVES

Our aim was to assess the number of follicular stelae of patients with AA and to evaluate their association with clinical type and severity and treatment response of AA.

MATERIALS AND METHODS

Histopathologic features including the number of follicular stelae were recorded in skin biopsies taken from lesions of AA in 142 patients who attended our dermatology clinic from 2011 to 2017.

RESULTS

There was a statistically significant correlation between patient age and the number of follicular stelae ( = 0.001). There was a statistically significant correlation between the severity of disease and number of follicular stelae ( = 0.005). AA subtypes (0%-25% scalp hair loss) had a significantly lower number of follicular stelae than 75%-100% of scalp hair loss and alopecia universalis (7.92 ± 4.21 vs. 13.23 ± 7.28). There was no statistically significant correlation between treatment response and the number of follicular stelae ( = 0.75).

CONCLUSION

Our results showed that the number of follicular stelae varied among AA clinical types and correlated with severity. This study was the first to evaluate the correlation between the number of follicular stelae and severity of AA.

摘要

背景

斑秃（AA）是一种自身免疫性疾病，其特征为毛囊周围淋巴细胞浸润、毛囊小型化、生长期/休止期毛囊以及皮肤活检中毛囊柱（条索）增加。

目的

我们的目的是评估斑秃患者的毛囊柱数量，并评估其与斑秃的临床类型、严重程度及治疗反应之间的关联。

材料与方法

记录了2011年至2017年在我们皮肤科诊所就诊的142例斑秃患者皮损处皮肤活检的组织病理学特征，包括毛囊柱数量。

结果

患者年龄与毛囊柱数量之间存在统计学显著相关性（P = 0.001）。疾病严重程度与毛囊柱数量之间存在统计学显著相关性（P = 0.005）。斑秃亚型（头皮脱发0%-25%）的毛囊柱数量显著低于头皮脱发75%-100%和全秃患者（7.92±4.21对13.23±7.28）。治疗反应与毛囊柱数量之间无统计学显著相关性（P = 0.75）。

结论

我们的结果表明，毛囊柱数量在斑秃临床类型之间存在差异，且与严重程度相关。本研究首次评估了毛囊柱数量与斑秃严重程度之间的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50d7/11335049/ad185b31266c/IJT-15-191-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50d7/11335049/12de0555d719/IJT-15-191-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50d7/11335049/ad185b31266c/IJT-15-191-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50d7/11335049/12de0555d719/IJT-15-191-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50d7/11335049/ad185b31266c/IJT-15-191-g002.jpg

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本文引用的文献

1
Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis.斑秃：疾病特征、临床评估及发病机制的新观点。
J Am Acad Dermatol. 2018 Jan;78(1):1-12. doi: 10.1016/j.jaad.2017.04.1141.
2
Elastic Staining in Differentiating Between Follicular Streamers and Follicular Scars in Horizontal Scalp Biopsy Sections.水平头皮活检切片中弹性染色在区分毛囊束与毛囊瘢痕中的应用
Am J Dermatopathol. 2018 Apr;40(4):254-258. doi: 10.1097/DAD.0000000000000973.
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Alopecia areata.斑秃。
Nat Rev Dis Primers. 2017 Mar 16;3:17011. doi: 10.1038/nrdp.2017.11.
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Diagnostic usefulness of a peribulbar eosinophilic infiltrate in alopecia areata.眶周嗜酸性细胞浸润对斑秃的诊断价值。
JAMA Dermatol. 2014 Sep;150(9):952-6. doi: 10.1001/jamadermatol.2014.62.
5
Epidemiologic and genetic characteristics of alopecia areata (part 1).斑秃的流行病学和遗传学特征（第1部分）
Acta Dermatovenerol Alp Pannonica Adriat. 2011;20(4):191-8.
6
Histologic features of alopecia areata other than peribulbar lymphocytic infiltrates.除了眶周淋巴细胞浸润外的斑秃的组织学特征。
J Am Acad Dermatol. 2011 Sep;65(3):615-620. doi: 10.1016/j.jaad.2011.02.017. Epub 2011 Jun 17.
7
Follicular streamers (stelae) in scarring and non-scarring alopecia.瘢痕性和非瘢痕性脱发中的毛囊束（柱状结构）
J Cutan Pathol. 2008 Dec;35(12):1115-20. doi: 10.1111/j.1600-0560.2008.00987.x. Epub 2008 Jun 19.
8
Histopathologic evaluation of alopecias.脱发的组织病理学评估。
Am J Dermatopathol. 2006 Jun;28(3):236-59. doi: 10.1097/00000372-200606000-00051.
9
Histopathologic features of alopecia areata: a new look.斑秃的组织病理学特征：新视角
Arch Dermatol. 2003 Dec;139(12):1555-9. doi: 10.1001/archderm.139.12.1555.
10
Eosinophils in fibrous tracts and near hair bulbs: a helpful diagnostic feature of alopecia areata.纤维束和毛囊附近的嗜酸性粒细胞：斑秃的一项有用诊断特征。
J Am Acad Dermatol. 1997 Jul;37(1):101-6. doi: 10.1016/s0190-9622(97)70219-6.