Agarwal Prashant
Dermadent Clinic, Udaipur, Rajasthan, India.
Int J Trichology. 2023 Sep-Oct;15(5):194-196. doi: 10.4103/ijt.ijt_77_23. Epub 2024 Jul 11.
Alopecia universalis (AU) is a rare form of hair loss characterized by the complete absence of hair on the scalp and body. It is an advanced form of alopecia areata. There is currently no definitive treatment for this condition, and management options are limited. This case report describes the successful treatment of a 37-year-old female patient with AU using oral tofacitinib 5 mg BID, an oral Janus kinase inhibitor. The patient experienced clinically significant hair regrowth on the scalp and eyebrows after 6 months of treatment with tofacitinib, along with the concurrent use of oral mini-pulse betamethasone, topical minoxidil 5%, and clobetasol lotion. This case highlights the potential efficacy of tofacitinib as a promising therapeutic option for AU, without notable safety concerns. Moreover, it is also well tolerated in this patient.
全秃（AU）是一种罕见的脱发形式，其特征是头皮和身体完全没有毛发。它是斑秃的一种严重形式。目前针对这种病症尚无确切的治疗方法，治疗选择有限。本病例报告描述了一名37岁的全秃女性患者使用口服托法替布5毫克每日两次（一种口服的Janus激酶抑制剂）成功治疗的情况。在用托法替布治疗6个月后，同时使用口服小剂量脉冲倍他米松、5%外用米诺地尔和氯倍他索洗剂，患者头皮和眉毛出现了临床上显著的毛发再生。本病例突出了托法替布作为全秃一种有前景的治疗选择的潜在疗效，且无明显安全问题。此外，该患者对其耐受性也良好。
