El-Tatawy Rania Ahmed, Gheida Shereen, Soliman Ghada Adbel Moamen, Ismail Mayada
Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Department of Clinical Patholog, Faculty of Medicine, Tanta University, Tanta, Egypt.
Int J Trichology. 2023 Sep-Oct;15(5):183-190. doi: 10.4103/ijt.ijt_92_22. Epub 2024 Jul 11.
Telogen effluvium (TE) is the most common hair loss. Vitamin D is related to hair and skin diseases due to its immunomodulatory and anti-inflammatory effects.
To investigate Vitamin D serum level role in TE pathogenesis.
Forty females with TE were collected and twenty age- and sex-matched healthy individuals as controls. Serum 25(OH) Vitamin D level was estimated prior and 3 months after oral Vitamin D.
The mean serum 25(OH) Vitamin D levels were significantly lower in TE patients than controls (13.31 ± 5.8 ng/ml vs. 33.61 ± 8.16 ng/ml) respectively, < 0.001. The mean serum 25(OH) Vitamin D levels before treatment in acute TE was 12.31 ± 6.88 ng/ml, compared to 10.6 ± 3.9 ng/ml in chronic TE without a significant difference, ( = 0.544). The mean serum 25(OH) Vitamin D levels in TE group after 3 months oral Vitamin D therapy were 38.4 ± 15.22 ng/ml with significant increase compared to pretreatment level, ( < 0.001). However, without a significant difference between acute TE (45.4 ± 9.22 ng/ml) and chronic TE (42.1 ± 10.6 ng/ml), ( = 0.711).
Oral Vitamin D has a promising effect in TE treatment, but the results need to be verified on a larger scale with evidence-based recommendation regarding the exact dose and treatment duration.
休止期脱发（TE）是最常见的脱发类型。维生素D因其免疫调节和抗炎作用而与毛发及皮肤疾病相关。
探讨血清维生素D水平在TE发病机制中的作用。
收集40例TE女性患者，并选取20例年龄和性别匹配的健康个体作为对照。在口服维生素D之前及之后3个月测定血清25(OH)维生素D水平。
TE患者的血清25(OH)维生素D平均水平显著低于对照组（分别为13.31±5.8 ng/ml和33.61±8.16 ng/ml），<0.001。急性TE患者治疗前的血清25(OH)维生素D平均水平为12.31±6.88 ng/ml，慢性TE患者为10.6±3.9 ng/ml，无显著差异（=0.544）。TE组口服维生素D治疗3个月后的血清25(OH)维生素D平均水平为38.4±15.22 ng/ml，与治疗前水平相比显著升高（<0.001）。然而，急性TE（45.4±9.22 ng/ml）和慢性TE（42.1±10.6 ng/ml）之间无显著差异（=0.711）。
口服维生素D对TE治疗有显著效果，但结果需要在更大规模上进行验证，并给出关于确切剂量和治疗持续时间的循证推荐。
