Sargazi Shahnaz, Mirzaei Ramazan, Mohammadi Mahdi, Rahmani Mashaallah
Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Environmental Sciences and Technology Research, Center, Department of Environmental Health Engineering, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Heliyon. 2024 Jul 25;10(15):e35097. doi: 10.1016/j.heliyon.2024.e35097. eCollection 2024 Aug 15.
Dialkyl phthalate esters are incorporated to enhance the pliability and prevent brittleness in polyvinyl chloride (PVC) tubing. Exposure to these compounds occurs throughout human lifetimes via ingestion, inhalation, and direct skin contact. A study was conducted to evaluate concentrations of four specific phthalates-dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP)-in the indoor air of both industrial and administrative sectors within the PVC manufacturing facilities. Air sampling was conducted in the spring season at two polyethylene factories in Zahedan Industrial Park (Sistan and Baluchestan Province, Iran). The outcomes demonstrated that mean concentrations of these substances in industrial along with administrative departments 485.7 μg/m and 49.83 μg/mfor DMP, 807.38 μg/m and 30.17 μg/m for DEP, 849.62 μg/m and 37.50 μg/m for DBP along with 1268.08 μg/m and 45.50 μg/m for DEHP respectively. The probabilistic lifetime cancer risk (LTCR) of DEHP in the indoor air of Zahedan PVC factories for men and women was determined using the Monte Carlo simulation technique. The computed mean LTCRs of DEHP for men and women in the indoor air of industrial and administrative departments in Zahedan PVC were 1.3 × 10, 1.2 × 10and 4.7 × 10,4.2 × 10respectively. Data showed that DEHP was a potential risk to human health.
邻苯二甲酸二烷基酯被添加到聚氯乙烯（PVC）管材中以增强柔韧性并防止变脆。在人的一生中，通过摄入、吸入和直接皮肤接触都会接触到这些化合物。开展了一项研究，以评估PVC制造设施内工业和行政部门室内空气中四种特定邻苯二甲酸盐——邻苯二甲酸二甲酯（DMP）、邻苯二甲酸二乙酯（DEP）、邻苯二甲酸二正丁酯（DBP）和邻苯二甲酸二（2-乙基己基）酯（DEHP）——的浓度。春季在扎赫丹工业园区（伊朗锡斯坦-俾路支斯坦省）的两家聚乙烯工厂进行了空气采样。结果表明，这些物质在工业部门和行政部门的平均浓度分别为：DMP为485.7μg/m³和49.83μg/m³，DEP为807.38μg/m³和30.17μg/m³，DBP为849.62μg/m³和37.50μg/m³，DEHP为1268.08μg/m³和45.50μg/m³。使用蒙特卡洛模拟技术确定了扎赫丹PVC工厂室内空气中DEHP对男性和女性的概率终身癌症风险（LTCR）。扎赫丹PVC工业和行政部门室内空气中男性和女性DEHP的计算平均LTCR分别为1.3×10⁻⁶、1.2×10⁻⁶和4.7×10⁻⁷、4.2×10⁻⁷。数据表明，DEHP对人类健康构成潜在风险。
