Yuan Man, Dong Guowei, Han Ning, Yan Libo, Tang Hong
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
Department of Infectious Diseases, Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, China.
Heliyon. 2024 Aug 2;10(15):e35616. doi: 10.1016/j.heliyon.2024.e35616. eCollection 2024 Aug 15.
is a nonculturable, nontuberculous mycobacterium that occasionally causes serious infections in individuals with immune deficiencies. Owing to its nonculturable nature, its antimicrobial susceptibility has not been assessed, and the optimal treatment regimen is unclear. Herein, we report a case of disseminated infection in a person with AIDS, identified using metagenomics next-generation sequencing (mNGS) and polymerase chain reaction (PCR).
A 33-year-old man presented with a 3-month history of abdominal pain, lymphadenopathy, intermittent night hot flashes, night sweats, and weight loss. No pathogen was detected during initial routine investigations. was subsequently identified in a left cervical lymph node sample using mNGS. Furthermore, infection was detected in a bone marrow sample based on PCR of and gene sequencing. The person was treated with a combination of moxifloxacin, clarithromycin, ethambutol, rifabutin, and amikacin. The laboratory results improved, and the patient's symptoms resolved.
may be missed in diagnostic tests because it cannot be grown using routine culture techniques. Early diagnosis and timely and effective treatment are critical in patients with infection; therefore, molecular techniques are recommended for patients with suspected infection.
[具体细菌名称未给出]是一种不可培养的非结核分枝杆菌，偶尔会在免疫缺陷个体中引起严重感染。由于其不可培养的特性，尚未评估其抗菌药敏性，最佳治疗方案也不明确。在此，我们报告一例艾滋病患者播散性[具体细菌名称未给出]感染病例，通过宏基因组学下一代测序（mNGS）和聚合酶链反应（PCR）进行鉴定。
一名33岁男性，有3个月的腹痛、淋巴结病、间歇性夜间潮热、盗汗和体重减轻病史。初次常规检查未检测到病原体。随后通过mNGS在左侧颈淋巴结样本中鉴定出[具体细菌名称未给出]。此外，基于[具体细菌名称未给出]的PCR和基因测序，在骨髓样本中检测到[具体细菌名称未给出]感染。该患者接受了莫西沙星、克拉霉素、乙胺丁醇、利福布汀和阿米卡星联合治疗。实验室结果改善，患者症状缓解。
[具体细菌名称未给出]可能在诊断测试中被漏诊，因为它不能用常规培养技术培养。对于[具体细菌名称未给出]感染患者，早期诊断以及及时有效的治疗至关重要；因此，对于疑似[具体细菌名称未给出]感染的患者，推荐使用分子技术。
