Kolditz M, Halank M, Spornraft-Ragaller P, Schmidt H, Höffken G
Dept. of Pulmonology, University Hospital Carl Gustav Carus, Fetscherstr. 74, 01307 Dresden, Germany.
Infection. 2005 Aug;33(4):278-81. doi: 10.1007/s15010-005-4118-0.
The case of an HIV-infected patient with low CD4+ cell count and localized pulmonary infection associated with Mycobacterium tilburgii, a recently recognized atypical mycobacterial species, is reported. Diagnosis was confirmed by repeated detection of mycobacterial DNA in lung biopsy specimens. After surgical removal of the pulmonary nodules, treatment with antimycobacterial combination therapy led to a complete and sustained recovery of the respiratory symptoms.M. tilburgii so far has only been described to cause disseminated infection in three patients, two of them suffering from acquired immunodeficiency syndrome. To our knowledge, this is the first report of localized pulmonary disease attributed to this mycobacterial species. As it responds to antimycobacterial combination therapy, efforts to establish the diagnosis using PCR methods in patients with suspected pulmonary disease due to mycobacteria other than tuberculosis should be undertaken.
报告了1例HIV感染患者，其CD4+细胞计数低，伴有与蒂尔堡分枝杆菌相关的局限性肺部感染，蒂尔堡分枝杆菌是最近发现的一种非典型分枝杆菌。通过在肺活检标本中反复检测分枝杆菌DNA确诊。手术切除肺结节后，抗分枝杆菌联合治疗使呼吸道症状完全且持续缓解。迄今为止，仅描述了3例蒂尔堡分枝杆菌引起播散性感染的病例，其中2例患有获得性免疫缺陷综合征。据我们所知，这是首例归因于该分枝杆菌的局限性肺部疾病报告。由于其对抗分枝杆菌联合治疗有反应，对于疑似非结核分枝杆菌所致肺部疾病的患者，应努力采用PCR方法进行诊断。
