肽菌素类抗生素的分子结构：对应于Emerimicins III和IV的2-9序列的八肽的溶液构象和晶体结构。

Molecular structure of peptaibol antibiotics: solution conformation and crystal structure of the octapeptide corresponding to the 2-9 sequence of emerimicins III and IV.

作者信息

Toniolo C, Bonora G M, Bavoso A, Benedetti E, di Blasio B, Pavone V, Pedone C

机构信息

Biopolymer Research Center, C.N.R., Institute of Organic Chemistry, University of Padova, Italy.

出版信息

J Biomol Struct Dyn. 1985 Dec;3(3):585-98. doi: 10.1080/07391102.1985.10508446.

DOI:10.1080/07391102.1985.10508446

PMID:3917040

Abstract

The infrared absorption and 1H nuclear magnetic resonance analyses of chloroform solutions of the terminally-blocked segment corresponding to the 2-9 sequence of emerimicins III and IV, -(Aib)3-L-Val-Gly-L-Leu-(Aib)2-, are consistent with the presence of a 3(10)-helical structure of high thermal stability. The crystal structure of the octapeptide, obtained by X-ray diffraction indicates the formation of a right-handed 3(10)-helix, stabilized by six consecutive intramolecular N-H....O:C H-bonds, slightly distorted at the level of the L-Leu residue.

摘要

对对应于埃默里霉素III和IV的2-9序列的末端封闭片段-(Aib)3-L-缬氨酸-Gly-L-亮氨酸-(Aib)2-的氯仿溶液进行红外吸收和1H核磁共振分析，结果与高热稳定性的3(10)-螺旋结构的存在一致。通过X射线衍射获得的八肽晶体结构表明形成了右手3(10)-螺旋，由六个连续的分子内N-H....O:C氢键稳定，在L-亮氨酸残基水平略有扭曲。