Gao Biao, Li Chenqi, Qu Yicui, Cai Mengyu, Zhou Qicheng, Zhang Yinyin, Lu Hongtao, Tang Yuxiao, Li Hongxia, Shen Hui
Department of Naval Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Teaching and Research Support Center, Naval Medical University, Shanghai, 200433, China.
Heliyon. 2024 Jul 31;10(15):e35469. doi: 10.1016/j.heliyon.2024.e35469. eCollection 2024 Aug 15.
To explore the research progress and trends on mineral elements and depression.
After querying the MeSH database and referring to the search rules, the search terms were selected and optimized to obtain the target literature collection. We analyzed the general characteristics of the literature, conducted network clustering and co-occurrence analysis, and carried out a narrative review of crucial literature.
Bipolar disorder was a dominant topic in the retrieved literature, which saw a significant increase in 2010 and 2019-2020. Most studies focused on mineral elements, including lithium, calcium, magnesium, zinc, and copper. The majority of journals and disciplines were in the fields of psychiatry, neuropsychology, neuropharmacology, nutrition, medical informatics, chemistry, and public health. The United States had the highest proportion in terms of paper sources, most-cited articles, high-frequency citations, frontier citations, and high centrality citation. Regarding the influence of academic institutions, the top five were King's College London, the Chinese Academy of Sciences, University of Barcelona, INSERM, and Heidelberg University. Frontier keywords included bipolar disorder, drinking water, (neuro)inflammation, gut microbiota, and systematic analysis. Research on lithium response, magnesium supplementation, and treatment-resistant unipolar depression increased significantly after 2013.
Global adverse events may have indirectly driven the progress in related research. Although the literature from the United States represents an absolute majority, its influence on academic institutions is relatively weaker. Multiple pieces of evidence support the efficacy of lithium in treating bipolar disorder (BD). A series of key discoveries have led to a paradigm shift in research, leading to increasingly detailed studies on the role of magnesium, calcium, zinc, and copper in the treatment of depression. Most studies on mineral elements remain diverse and inconclusive. The potential toxicity and side effects of some elements warrant careful attention.
探讨矿物质元素与抑郁症的研究进展及趋势。
查询MeSH数据库并参照检索规则，选择并优化检索词以获取目标文献集。我们分析了文献的一般特征，进行了网络聚类和共现分析，并对关键文献进行了叙述性综述。
双相情感障碍是检索文献中的主导主题，在2010年以及2019 - 2020年有显著增加。大多数研究集中在矿物质元素，包括锂、钙、镁、锌和铜。大多数期刊和学科领域为精神病学、神经心理学、神经药理学、营养学、医学信息学、化学和公共卫生。就论文来源、被引频次最高的文章、高频被引、前沿被引和高中心性被引而言，美国所占比例最高。关于学术机构的影响力，排名前五的是伦敦国王学院、中国科学院、巴塞罗那大学、法国国家健康与医学研究院以及海德堡大学。前沿关键词包括双相情感障碍、饮用水、（神经）炎症、肠道微生物群和系统分析。2013年后，关于锂反应、镁补充以及难治性单相抑郁症的研究显著增加。
全球不良事件可能间接推动了相关研究的进展。尽管来自美国的文献占绝对多数，但其对学术机构的影响力相对较弱。多项证据支持锂治疗双相情感障碍（BD）的疗效。一系列关键发现导致了研究范式的转变，促使对镁、钙、锌和铜在抑郁症治疗中的作用进行越来越详细的研究。大多数关于矿物质元素的研究仍然多样且尚无定论。一些元素的潜在毒性和副作用值得密切关注。
