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应用FROZENIX部分象鼻支架行两阶段手术治疗复发性B型主动脉夹层合并显微镜下多血管炎患者的冷冻象鼻技术及开放降主动脉置换术:病例报告

Two-Stage Surgery Using FROZENIX Partial ET for Frozen Elephant Trunk Technique and Open Descending Aortic Replacement in a Patient With Recurrent Type B Aortic Dissection and Microscopic Polyangiitis: A Case Report.

作者信息

Kinoshita Ryoji, Watanabe Taiju, Matsumoto Ryumon, Hirooka Kazunobu

机构信息

Cardiovascular Surgery, Tsuchiura Kyodo General Hospital, Tsuchiura, JPN.

Cardiac Surgery, Tsuchiura Kyodo General Hospital, Tsuchiura, JPN.

出版信息

Cureus. 2024 Aug 17;16(8):e67055. doi: 10.7759/cureus.67055. eCollection 2024 Aug.

Abstract

The frozen elephant trunk (FET) technique, initially developed as a one-stage procedure to treat extensive thoracic aortic aneurysms, has since been adapted to address acute and chronic aortic dissections by closing entry tears and expanding the true lumen. It has become widely adopted due to its effectiveness in managing aortic diseases. We present the case of a 39-year-old female with microscopic polyangiitis (MPA) who developed recurrent type B aortic dissection accompanied by rapid expansion. The patient, a compromised host with multiple comorbidities such as glomerulonephritis, chronic renal failure, alveolar hemorrhage, and acute pancreatitis, required urgent surgical intervention. Given the complexity of her condition and the high risks associated with direct surgery, a staged approach was selected. The first stage involved using a novel FET prosthesis, the FROZENIX Partial ET (FPET), inserted via median sternotomy, followed by a left thoracotomy for non-deep hypothermic circulatory arrest (non-DHCA) descending aortic replacement. The surgery led to favorable outcomes without any major complications or sequelae. FPET offers distinct advantages in this complex scenario. Its design features a 2 cm stent-free distal section, which reduces the risk of distal stent graft-induced new entries (dSINEs) and simplifies anastomosis during the second stage of surgery. For patients with severe comorbidities and anatomical challenges that make the thoracic endovascular aortic repair (TEVAR) unsuitable, a staged open surgical approach is a viable alternative, mitigating the risks linked to DHCA. This case underscores the utility of a staged surgical approach using FPET in managing complicated chronic type B aortic dissection in patients with significant comorbidities. The FPET prosthesis facilitates effective lesion control while minimizing the risk of dSINEs and streamlining subsequent surgical procedures, presenting a promising strategy for similar complex cases.

摘要

冷冻象鼻(FET)技术最初是作为一种治疗广泛性胸主动脉瘤的一期手术方法而开发的,此后已被应用于通过封闭入口撕裂和扩大真腔来治疗急性和慢性主动脉夹层。由于其在治疗主动脉疾病方面的有效性,它已被广泛采用。我们报告一例39岁患有显微镜下多血管炎(MPA)的女性患者,该患者发生复发性B型主动脉夹层并伴有快速扩张。该患者是一位存在多种合并症的脆弱宿主,如肾小球肾炎、慢性肾衰竭、肺泡出血和急性胰腺炎,需要紧急手术干预。鉴于其病情的复杂性以及直接手术相关的高风险,选择了分期手术方法。第一阶段采用一种新型FET假体,即FROZENIX部分象鼻(FPET),通过正中胸骨切开术插入,随后通过左胸切开术进行非深低温循环停搏(non-DHCA)下行主动脉置换。手术取得了良好的效果,没有任何重大并发症或后遗症。FPET在这种复杂情况下具有明显优势。其设计特点是远端有2厘米无支架段,这降低了远端支架移植物引起新入口(dSINEs)的风险,并简化了手术第二阶段的吻合。对于患有严重合并症且解剖结构复杂而使胸主动脉腔内修复术(TEVAR)不适用的患者,分期开放手术方法是一种可行的替代方案,可减轻与DHCA相关的风险。该病例强调了使用FPET的分期手术方法在治疗患有严重合并症的复杂慢性B型主动脉夹层中的实用性。FPET假体有助于有效控制病变,同时将dSINEs的风险降至最低,并简化后续手术程序,为类似复杂病例提供了一种有前景的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/521e/11336251/849189dd8909/cureus-0016-00000067055-i01.jpg

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