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基于人工智能的间充质干细胞（MSCs）衍生外泌体研究全球趋势的文献计量分析：2014 - 2023年

Artificial intelligence (AI)-powered bibliometric analysis of global trends in mesenchymal stem cells (MSCs)-derived exosome research: 2014-2023.

作者信息

Tsai Shih-Chang, Wan Bing-Han, Tsai Fuu-Jen, Yang Jai-Sing

机构信息

Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.

出版信息

Biomedicine (Taipei). 2024 Dec 1;14(4):61-77. doi: 10.37796/2211-8039.1470. eCollection 2024.

DOI:10.37796/2211-8039.1470
PMID:39777112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11703396/
Abstract

INTRODUCTION

In recent years, significant progress has been made in regenerative medicine, specifically in using mesenchymal stem cells (MSCs) due to their regenerative and differentiating abilities. An exciting development in this area is the utilization of exosomes derived from MSCs, which have shown promise in tissue restoration, immune system modulation, and cancer treatment.

OBJECTIVES

This study aims to analyze global research trends and the academic impact of MSCs-derived exosomes from 2014 to 2023, providing a comprehensive overview of this emerging field.

MATERIALS AND METHODS

The Web of Science database selected 948 relevant publications from 2014 to 2023. Artificial intelligence (AI)-bibliometric tools, including Bibliometrix, CiteSpace, and VOSviewer, were employed to analyze and visualize the data. The focus was on publication quantity, research nations, institutional partnerships, keywords, and research focal points.

RESULTS

The study revealed that China, Japan, Taiwan, and the United States are the leaders in publication volume and impact in MSCs-derived exosome research. China has the highest number of publications, while the United States and Iran excel in research quality and influence. Primary research themes were identified through keyword and clustering analyses, including tissue repair, immune modulation, bone regeneration, and cancer treatment. The study also emphasized the importance of international collaboration, with China and the United States demonstrating the most robust cooperation.

CONCLUSION

MSCs-derived exosome research rapidly expands worldwide, showing promising prospects in regenerative medicine and cell therapy. With continued research and international collaboration, MSCs-derived exosomes are expected to play a vital role in future therapeutic application.

摘要

引言

近年来，再生医学取得了重大进展，特别是在利用间充质干细胞（MSC）方面，因为它们具有再生和分化能力。该领域一个令人兴奋的发展是利用源自MSC的外泌体，其在组织修复、免疫系统调节和癌症治疗方面已显示出前景。

目的

本研究旨在分析2014年至2023年间源自MSC的外泌体的全球研究趋势和学术影响，全面概述这一新兴领域。

材料与方法

科学网数据库选取了2014年至2023年的948篇相关出版物。使用包括Bibliometrix、CiteSpace和VOSviewer在内的人工智能文献计量工具对数据进行分析和可视化。重点关注出版物数量、研究国家、机构合作、关键词和研究重点。

结果

研究表明，中国、日本、台湾地区和美国在源自MSC的外泌体研究的出版物数量和影响力方面处于领先地位。中国的出版物数量最多，而美国和伊朗在研究质量和影响力方面表现出色。通过关键词和聚类分析确定了主要研究主题，包括组织修复、免疫调节、骨再生和癌症治疗。该研究还强调了国际合作的重要性，中国和美国展现出最强大的合作。

结论

源自MSC的外泌体研究在全球迅速扩展，在再生医学和细胞治疗方面显示出广阔前景。随着持续研究和国际合作，源自MSC的外泌体有望在未来治疗应用中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aeb/11703396/0c4196c9c818/bmed-14-04-061f13.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aeb/11703396/2ecbe5b56c5e/bmed-14-04-061f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aeb/11703396/a0c7d97bbc78/bmed-14-04-061f11.jpg
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