Gilis Xavier, Servais Thomas, Pierman Guillaume, Nollevaux Marie-Cécile, Delgrange Etienne
Department of Endocrinology, CHU UCL Namur (Godinne), Université catholique de Louvain, 5530 Yvoir, Belgium.
Department of Pathology, CHU UCL Namur (Godinne), Université catholique de Louvain, 5530 Yvoir, Belgium.
JCEM Case Rep. 2024 Aug 21;2(9):luae149. doi: 10.1210/jcemcr/luae149. eCollection 2024 Sep.
Adrenal incidentalomas are a frequent cause for consultation in endocrinology. Current guidelines provide an algorithm for their evaluation to determinate the risk of hormonally active or malignant condition. We report a unique case of benign adrenal incidentaloma in a 53-year-old woman with multiple malignancy criteria on contrast-free computed tomography and [F]fluorodeoxyglucose positron emission tomography-computed tomography, leading to a left adrenalectomy. Histopathologic analysis showed a 15-mm intra-adrenal lymphoid organ localized in the medulla, without any cellular atypia and organized with a capsule and multiple germinal centers. The surrounding adrenal tissue was unremarkable, and the patient did not develop any inflammatory, infectious, or neoplastic disease during the 2 following years. This is the first described case of a well-organized intra-adrenal ectopic lymphoid organ in the absence of any evident stimulus.
肾上腺偶发瘤是内分泌科常见的会诊原因。当前指南提供了一种评估算法，以确定其发生激素活性或恶性病变的风险。我们报告了一例独特的病例，一名53岁女性患有良性肾上腺偶发瘤，其在无对比剂计算机断层扫描和[F]氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描上有多个恶性标准，最终进行了左肾上腺切除术。组织病理学分析显示，一个15毫米的肾上腺内淋巴器官位于髓质，无任何细胞异型性，有包膜和多个生发中心。周围肾上腺组织无异常，患者在随后两年未发生任何炎症、感染或肿瘤性疾病。这是首次报道的在无任何明显刺激情况下组织良好的肾上腺内异位淋巴器官病例。
