Tuan Nguyen Huynh Nhat, Hai Tran Duc, Minh Le Nhat, Than Ton Long Hoang, Tu Pham Dang, Bao Nguyen Van Tien, Van Khoa Le, Dang Thai Ngoc, Van Phuoc Le
Department of radiology, Cho Ray Hospital, Ho Chi Minh City, Viet Nam.
Radiol Case Rep. 2024 Jul 27;19(10):4335-4340. doi: 10.1016/j.radcr.2024.06.086. eCollection 2024 Oct.
Desmoid fibromatosis (DFs) is rare, low-grade neoplasm. Although it poses no risk of metastasis, DFs exhibits a range of clinical manifestations characterized by local infiltrative growth tendencies and a propensity for recurrence. Despite its nonmalignant nature, DFs can be highly debilitating and occasionally life-threatening, causing severe pain and functional limitations. Traditionally, surgery served as the conventional primary treatment approach; nevertheless, a recent shift in paradigm towards a more conservative management has emerged, accompanied by efforts to standardize the strategy among clinicians. Systemic doxorubicin has been demonstrated to be effective in treating DFs; however, it carries potential risks of adverse effects on the cardiovascular, digestive, and hematologic systems. The novel intravascular intervention employing drug-eluting beads loaded with doxorubicin represents an effective treatment for DFs, optimizing drug delivery to the target lesion and reducing systemic toxicity. In this article, we present a rare case of DFs in the right pubic region treated with transarterial doxorubicin-eluting beads embolization.
韧带样型纤维瘤病（DFs）是一种罕见的低度恶性肿瘤。尽管它没有转移风险，但DFs表现出一系列临床表现，其特征为局部浸润性生长倾向和复发倾向。尽管DFs本质上并非恶性，但它可能极具致残性，偶尔还会危及生命，导致严重疼痛和功能受限。传统上，手术是常规的主要治疗方法；然而，最近出现了向更保守治疗模式的转变，同时临床医生也在努力使治疗策略标准化。已证明全身使用阿霉素对治疗DFs有效；然而，它对心血管、消化和血液系统存在潜在的不良反应风险。采用载有阿霉素的药物洗脱微球的新型血管内介入治疗是DFs的一种有效治疗方法，可优化药物向靶病变的递送并降低全身毒性。在本文中，我们介绍了一例经动脉阿霉素洗脱微球栓塞治疗的右侧耻骨区罕见DFs病例。
