Ponikowska Barbara, Biegus Jan, Fudim Marat, Iwanek Gracjan, Guzik Mateusz, Przybylski Roman, Szuba Andrzej, Chachaj Angelika, Zymliński Robert
Student Scientific Organization, Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
JACC Basic Transl Sci. 2024 May 22;9(7):906-917. doi: 10.1016/j.jacbts.2024.02.016. eCollection 2024 Jul.
The purpose of this study was to present a protocol for visualizing lymphatic flow in patients with heart failure (HF) by using indocyanine green fluorescence lymphography. We studied 37 subjects: 20 patients with acute heart failure (AHF) and lower limb edema, 7 patients with chronic heart failure (CHF) without lower limb edema, and 10 control subjects (no HF, no limb edema). All subjects were assessed at rest, and 11 subjects (6 control and 5 with CHF) were assessed again after a 10-minute walk. The lymph flow was visualized in all selected patients without complications. At rest, there was either no lymph flow or minimal lymph flow in all control subjects and patients with CHF, whereas the majority of patients with AHF demonstrated significant lymph flow. This study describes a new method to visualize/assess lymphatic flow in patients with HF, allowing for continuous, real-time tracking of lymphatic flow in the lower extremity.
本研究的目的是提出一种通过使用吲哚菁绿荧光淋巴管造影术来可视化心力衰竭（HF）患者淋巴流动的方案。我们研究了37名受试者：20例急性心力衰竭（AHF）伴下肢水肿患者、7例无下肢水肿的慢性心力衰竭（CHF）患者以及10名对照受试者（无HF，无肢体水肿）。所有受试者均在静息状态下进行评估，11名受试者（6名对照和5名CHF患者）在步行10分钟后再次进行评估。在所有选定患者中均成功实现了淋巴流动的可视化且无并发症发生。静息时，所有对照受试者和CHF患者均无淋巴流动或仅有极少的淋巴流动，而大多数AHF患者表现出显著的淋巴流动。本研究描述了一种可视化/评估HF患者淋巴流动的新方法，可对下肢淋巴流动进行连续、实时追踪。
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