人主动脉狭窄瓣膜来源的细胞外囊泡通过AT1R/烟酰胺腺嘌呤二核苷酸磷酸氧化酶/钠-葡萄糖协同转运蛋白2促氧化途径诱导内皮功能障碍和血栓形成倾向。

Human Aortic Stenotic Valve-Derived Extracellular Vesicles Induce Endothelial Dysfunction and Thrombogenicity Through AT1R/NADPH Oxidases/SGLT2 Pro-Oxidant Pathway.

作者信息

Hmadeh Sandy, Trimaille Antonin, Matsushita Kensuke, Marchandot Benjamin, Carmona Adrien, Zobairi Fatiha, Sato Chisato, Kindo Michel, Hoang Tam Minh, Toti Florence, Zibara Kazem, Hamade Eva, Schini-Kerth Valérie, Kauffenstein Gilles, Morel Olivier

机构信息

UR 3074 Translational Cardiovascular Medicine, CRBS, Strasbourg, France.

Department of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.

出版信息

JACC Basic Transl Sci. 2024 May 29;9(7):845-864. doi: 10.1016/j.jacbts.2024.02.012. eCollection 2024 Jul.

Pathological tissues release a variety of factors, including extracellular vesicles (EVs) shed by activated or apoptotic cells. EVs trapped within the native pathological valves may act as key mediators of valve thrombosis. Human aortic stenosis EVs promote activation of valvular endothelial cells, leading to endothelial dysfunction, and proadhesive and procoagulant responses.