Abdullah Muntadher A, Kadhum Fatima J, Issa Sajjad S
College of Medicine, University of Basrah, Basrah Gastroenterology and Hepatology Hospital, Basrah, IRQ.
Medicine, Al-Fayhaa General Hospital, Basrah, IRQ.
Cureus. 2024 Jul 22;16(7):e65089. doi: 10.7759/cureus.65089. eCollection 2024 Jul.
Background Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases caused by the accumulation of fat in the liver, which can progress to fibrosis, cirrhosis, and primary liver cancer. Insulin resistance is a causative factor in the development of NAFLD. FibroScan, or transient elastography, is a noninvasive imaging technique for evaluating liver disease. Aim To use FibroScan for evaluating liver involvement in type 2 diabetes mellitus (T2DM) patients with some associated risk factors. Materials and methods A cross-sectional prospective study was conducted from February to August 2023 in the outpatient clinic of Basrah Gastroenterology and Hepatology Hospital. Data collection included demographic data, past medical history, and biochemical tests including fasting blood sugar (FBS), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lipid profile (consisting of low-density lipoprotein (LDL), high-density lipoprotein (HDL), serum triglycerides, and total cholesterol), then, patients underwent FibroScan examination. Results The study included 50 patients with T2DM, of whom 23 (46%) were male and 27 (54%) were female. The mean age of the studied population was 47.72 ± 8.31 years, with a range of 28-64 years. The mean BMI was 28.44 ± 4.24, with most patients being either overweight or obese. The fibrosis score was 4.74 ± 1.02 kPa (stage 0), while the mean steatosis score was 282.88 ± 44.99 (grade III). Diastolic blood pressure (BP), serum ALT, and serum HDL level were the variables that showed statistically significant differences when compared according to the stages of steatosis measured by FibroScan, with p-values of 0.016, 0.048, and 0.028, respectively. Conclusion Some risk factors associated with diabetes, such as dyslipidemia, liver enzymes, and BP, are highly associated with the development of steatosis rather than fibrosis.
背景 非酒精性脂肪性肝病（NAFLD）是一种因肝脏脂肪堆积而引发的肝脏疾病谱，可进展为肝纤维化、肝硬化和原发性肝癌。胰岛素抵抗是NAFLD发生发展的一个致病因素。FibroScan，即瞬时弹性成像，是一种用于评估肝脏疾病的非侵入性成像技术。目的 使用FibroScan评估伴有某些相关危险因素的2型糖尿病（T2DM）患者的肝脏受累情况。材料与方法 2023年2月至8月在巴士拉胃肠病与肝病医院门诊进行了一项横断面前瞻性研究。数据收集包括人口统计学数据、既往病史以及生化检查，包括空腹血糖（FBS）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和血脂谱（包括低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、血清甘油三酯和总胆固醇），然后，患者接受FibroScan检查。结果 该研究纳入了50例T2DM患者，其中23例（46%）为男性，27例（54%）为女性。研究人群的平均年龄为47.72±8.31岁，范围为28 - 64岁。平均体重指数为28.44±4.24，大多数患者超重或肥胖。纤维化评分4.74±1.02 kPa（0期），而平均脂肪变性评分282.88±44.99（III级）。根据FibroScan测量的脂肪变性阶段进行比较时，舒张压（BP）、血清ALT和血清HDL水平是显示出统计学显著差异的变量，p值分别为0.016、0.048和0.028。结论 一些与糖尿病相关的危险因素，如血脂异常、肝酶和血压，与脂肪变性的发生发展高度相关，而非肝纤维化。
