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代谢功能障碍相关脂肪性肝病患者牙周治疗后口腔扁平苔藓的改善:一例报告

Improvements in Oral Lichen Planus Following Periodontal Treatment in a Patient With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Case Report.

作者信息

Nagao Yumiko, Nakagaki Hitomi, Tomiyasu Nobuo, Tsuji Masahide

机构信息

Public Health, Graduate School of Medicine, Juntendo University Faculty of Medicine, Tokyo, JPN.

Dental and Oral Surgery, Tsuji Dental and Oral Surgery Clinic, Omuta, JPN.

出版信息

Cureus. 2024 Jul 21;16(7):e65054. doi: 10.7759/cureus.65054. eCollection 2024 Jul.

DOI:10.7759/cureus.65054
PMID:39171017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11336511/
Abstract

Oral lichen planus (OLP), a chronic inflammatory mucocutaneous disease, is known to be associated with liver disease. Additionally, associations between periodontal disease and metabolic dysfunction-associated steatotic liver disease (MASLD), as well as cardiovascular disease, have been reported. Herein, we report a case of a 68-year-old male who presented at a dental clinic with OLP, which showed signs of improvement after treatment for periodontal disease. The patient had hepatic dysfunction and steatosis, which was complicated by angina pectoris. He was diagnosed with OLP and periodontal disease. Subsequent close examination of his liver led to a diagnosis of MASLD. Treatment for periodontal disease and enhanced oral self-care improved the OLP lesions and liver function values. This case demonstrates that collaboration between different medical disciplines can significantly impact patient health.

摘要

口腔扁平苔藓(OLP)是一种慢性炎症性黏膜皮肤疾病,已知与肝脏疾病有关。此外,牙周病与代谢功能障碍相关脂肪性肝病(MASLD)以及心血管疾病之间的关联也有报道。在此,我们报告一例68岁男性病例,该患者因OLP就诊于牙科诊所,在接受牙周病治疗后症状有所改善。患者存在肝功能障碍和脂肪变性,并伴有心绞痛。他被诊断为OLP和牙周病。随后对其肝脏进行的仔细检查诊断为MASLD。牙周病治疗和加强口腔自我护理改善了OLP病变和肝功能指标。该病例表明不同医学学科之间的协作可对患者健康产生重大影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba64/11336511/e0e128d63cd3/cureus-0016-00000065054-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba64/11336511/802001c54480/cureus-0016-00000065054-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba64/11336511/2116bcce2e71/cureus-0016-00000065054-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba64/11336511/e0e128d63cd3/cureus-0016-00000065054-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba64/11336511/802001c54480/cureus-0016-00000065054-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba64/11336511/2116bcce2e71/cureus-0016-00000065054-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba64/11336511/e0e128d63cd3/cureus-0016-00000065054-i03.jpg

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本文引用的文献

1
Metabolic disease and the liver: A review.代谢性疾病与肝脏:综述
World J Hepatol. 2024 Jan 27;16(1):33-40. doi: 10.4254/wjh.v16.i1.33.
2
Prevalence of metabolic dysfunction-associated steatotic liver disease in the Middle East and North Africa.中东和北非地区代谢功能障碍相关脂肪性肝病的患病率
Liver Int. 2024 Apr;44(4):1061-1070. doi: 10.1111/liv.15852. Epub 2024 Feb 2.
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Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in a middle-aged population with overweight and normal liver enzymes, and diagnostic accuracy of noninvasive proxies.
代谢相关脂肪性肝病(MASLD)在超重且肝酶正常的中年人群中的流行情况,以及无创性替代指标的诊断准确性。
Medicine (Baltimore). 2024 Jan 5;103(1):e34934. doi: 10.1097/MD.0000000000034934.
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The role of microbiome in the pathogenesis of oral-gut-liver axis between periodontitis and nonalcoholic fatty liver disease.微生物群落在牙周炎与非酒精性脂肪性肝病之间的口腔-肠道-肝脏轴发病机制中的作用。
J Dent Sci. 2023 Jul;18(3):972-975. doi: 10.1016/j.jds.2023.03.012. Epub 2023 Mar 25.
5
Periodontitis salivary microbiota exacerbates nonalcoholic fatty liver disease in high-fat diet-induced obese mice.牙周炎唾液微生物群加剧高脂饮食诱导的肥胖小鼠的非酒精性脂肪性肝病。
iScience. 2023 Mar 7;26(4):106346. doi: 10.1016/j.isci.2023.106346. eCollection 2023 Apr 21.
6
Periodontal disease is associated with the risk of cardiovascular disease independent of sex: A meta-analysis.牙周病与心血管疾病风险相关,与性别无关:一项荟萃分析。
Front Cardiovasc Med. 2023 Feb 27;10:1114927. doi: 10.3389/fcvm.2023.1114927. eCollection 2023.
7
Periodontal Treatment and Usual Care for Nonalcoholic Fatty Liver Disease: A Multicenter, Randomized Controlled Trial.牙周治疗和非酒精性脂肪性肝病的常规护理:一项多中心、随机对照试验。
Clin Transl Gastroenterol. 2022 Nov 1;13(11):e00520. doi: 10.14309/ctg.0000000000000520.
8
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