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焦亡对结直肠癌发生、发展、侵袭和转移影响的研究进展

Research progress on the effect of pyroptosis on the occurrence, development, invasion and metastasis of colorectal cancer.

作者信息

Wang Xu, Yin Qi-Hang, Wan Lin-Lu, Sun Ruo-Lan, Wang Gang, Gu Jun-Fei, Tang De-Cai

机构信息

School of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.

Department of Ana and Intestine Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

出版信息

World J Gastrointest Oncol. 2024 Aug 15;16(8):3410-3427. doi: 10.4251/wjgo.v16.i8.3410.

DOI:10.4251/wjgo.v16.i8.3410
PMID:39171180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11334039/
Abstract

Pyroptosis is a type of programmed cell death mediated by gasdermines (GSDMs). The N-terminal domain of GSDMs forms pores in the plasma membrane, causing cell membrane rupture and the release of cell contents, leading to an inflammatory response and mediating pyrodeath. Pyroptosis plays an important role in inflammatory diseases and malignant tumors. With the further study of pyroptosis, an increasing number of studies have shown that the pyroptosis pathway can regulate the tumor microenvironment and antitumor immunity of colorectal cancer and is closely related to the occurrence, development, treatment and prognosis of colorectal cancer. This review aimed to explore the molecular mechanism of pyroptosis and the role of pyroptosis in the occurrence, development, treatment and prognosis of colorectal cancer (CRC) and to provide ideas for the clinical diagnosis and treatment of CRC.

摘要

细胞焦亡是一种由gasdermines（GSDMs）介导的程序性细胞死亡。GSDMs的N端结构域在质膜上形成孔道，导致细胞膜破裂和细胞内容物释放，引发炎症反应并介导细胞焦亡。细胞焦亡在炎症性疾病和恶性肿瘤中发挥重要作用。随着对细胞焦亡研究的深入，越来越多的研究表明，细胞焦亡途径可调节结直肠癌的肿瘤微环境和抗肿瘤免疫，与结直肠癌的发生、发展、治疗及预后密切相关。本综述旨在探讨细胞焦亡的分子机制及其在结直肠癌（CRC）发生、发展、治疗和预后中的作用，为CRC的临床诊断和治疗提供思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/108a68253c35/WJGO-16-3410-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/a280e93ca5a0/WJGO-16-3410-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/bfe943828132/WJGO-16-3410-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/9e27f63dfdae/WJGO-16-3410-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/8bb2708cca38/WJGO-16-3410-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/67fa3762ffe3/WJGO-16-3410-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/108a68253c35/WJGO-16-3410-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/a280e93ca5a0/WJGO-16-3410-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/bfe943828132/WJGO-16-3410-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/9e27f63dfdae/WJGO-16-3410-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/8bb2708cca38/WJGO-16-3410-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/67fa3762ffe3/WJGO-16-3410-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d33/11334039/108a68253c35/WJGO-16-3410-g006.jpg

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本文引用的文献

1
NR5A2 gene affects the overall survival of LUAD patients by regulating the activity of CSCs through SNP pathway by OCLR algorithm and immune score.NR5A2基因通过OCLR算法和免疫评分，经由SNP途径调节癌症干细胞活性，从而影响肺腺癌患者的总生存期。
Heliyon. 2024 Mar 28;10(7):e28282. doi: 10.1016/j.heliyon.2024.e28282. eCollection 2024 Apr 15.
2
Comparison of left- and right-sided colorectal cancer to explore prognostic signatures related to pyroptosis.比较左、右侧结直肠癌以探索与细胞焦亡相关的预后特征。
Heliyon. 2024 Mar 14;10(7):e28091. doi: 10.1016/j.heliyon.2024.e28091. eCollection 2024 Apr 15.
3
induces chemoresistance in colorectal cancer by inhibiting pyroptosis via the Hippo pathway.
通过抑制 Hippo 通路中的细胞焦亡来诱导结直肠癌细胞的化疗耐药性。
Gut Microbes. 2024 Jan-Dec;16(1):2333790. doi: 10.1080/19490976.2024.2333790. Epub 2024 Mar 27.
4
Identification and validation of a pyroptosis-related prognostic model for colorectal cancer based on bulk and single-cell RNA sequencing data.基于批量和单细胞RNA测序数据的结直肠癌焦亡相关预后模型的鉴定与验证
World J Clin Oncol. 2024 Feb 24;15(2):329-355. doi: 10.5306/wjco.v15.i2.329.
5
Pyroptosis: a new insight into intestinal inflammation and cancer.细胞焦亡：肠道炎症和癌症研究的新视角。
Front Immunol. 2024 Feb 22;15:1364911. doi: 10.3389/fimmu.2024.1364911. eCollection 2024.
6
The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy.基于纳米颗粒的铁死亡、细胞焦亡和自噬在癌症免疫治疗中的应用。
J Nanobiotechnology. 2024 Mar 7;22(1):97. doi: 10.1186/s12951-024-02297-8.
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Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation.智能响应型 Fe/Mn 纳米疫苗通过细胞焦亡和细胞焦亡增强的 cGAS-STING 激活触发肝癌免疫治疗。
J Nanobiotechnology. 2024 Mar 6;22(1):95. doi: 10.1186/s12951-024-02354-2.
8
Application of pyroptosis score in the treatment and prognosis evaluation of gastric cancer.焦亡评分在胃癌治疗及预后评估中的应用。
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Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer.线粒体靶向光动力疗法触发 GSDME 介导热激细胞死亡并增强结直肠癌的抗 PD-1 治疗效果。
J Immunother Cancer. 2024 Mar 1;12(3):e008054. doi: 10.1136/jitc-2023-008054.