Bottini E
Interdisciplinary Center for Applied Mathematics, 2nd University of Rome School of Medicine, Italy.
Exp Clin Immunogenet. 1985;2(2):70-6.
Adenosine deaminase (ADA) phenotype and ABO blood groups have been determined in 572 consecutive newborn infants, in 770 schoolchildren, in 139 women delivering a liveborn infant, and in 87 women with habitual abortion. ABO-incompatible newborn infants showed a higher proportion of ADA2 carriers as compared to compatible newborns. The incidence of clinically relevant neonatal jaundice among incompatible infants carrying ADA2 was lower as compared to compatible infants carrying this gene. In newborn infants, schoolchildren, and women with habitual abortion the proportion of A, B, and AB among ADA2 carriers was higher as compared to ADA1/ADA1 individuals. In fertile women, on the contrary, the proportion of A, B, and AB among ADA2 carriers was lower as compared to ADA1/ADA1 women. This suggests that non-O ADA2 carrier genotypes may lose in the reproductive stage the selective advantage accumulated during the early stages of development.
对572名连续出生的新生儿、770名学童、139名顺产活婴的妇女以及87名习惯性流产妇女进行了腺苷脱氨酶（ADA）表型和ABO血型测定。与血型相容的新生儿相比，血型不相容的新生儿中ADA2携带者的比例更高。携带ADA2的血型不相容婴儿中临床相关新生儿黄疸的发生率低于携带该基因的血型相容婴儿。在新生儿、学童和习惯性流产妇女中，与ADA1/ADA1个体相比，ADA2携带者中A、B和AB血型的比例更高。相反，在可育妇女中，与ADA1/ADA1妇女相比，ADA2携带者中A、B和AB血型的比例更低。这表明非O型ADA2携带者基因型可能在生殖阶段失去在发育早期积累的选择优势。
