Feng Jia, Xi Long-Long, Lu Chuan-Jun, Liu Ren-Rong
College of Chemistry and Chemical Engineering, Qingdao University, Ningxia Road 308#, Qingdao 266071, China.
Key Laboratory of Shandong Provincial Universities for Functional Molecules and Materials, Qingdao University, Qingdao 266071, China.
Chem Soc Rev. 2024 Sep 30;53(19):9560-9581. doi: 10.1039/d4cs00102h.
Chiral amine scaffolds are among the most important building blocks in natural products, drug molecules, and functional materials, which have prompted chemists to focus more on their synthesis. Among the accomplishments in chiral amine synthesis, transition-metal-catalyzed enantioselective C-N cross-coupling is considered one of the most efficient protocols. This approach combines traditional C(sp)-N cross-coupling methods (such as the Buchwald-Hartwig reaction Ullmann-type reaction, and Chan-Evans-Lam reaction), aryliodonium salt chemistry and radical chemistry, providing an attractive pathway to a wide range of structurally diverse chiral amines with high enantioselectivity. This review summarizes the established protocols and offers a comprehensive outlook on the promising enantioselective C-N cross-coupling reaction.
手性胺骨架是天然产物、药物分子和功能材料中最重要的结构单元之一，这促使化学家们更加关注它们的合成。在手性胺合成的诸多成果中，过渡金属催化的对映选择性C-N交叉偶联被认为是最有效的方法之一。这种方法结合了传统的C(sp)-N交叉偶联方法（如布赫瓦尔德-哈特维希反应、乌尔曼型反应和陈-埃文斯-拉姆反应）、芳基碘鎓盐化学和自由基化学，为合成各种结构多样的高对映选择性手性胺提供了一条具有吸引力的途径。本文综述了已确立的方法，并对有前景的对映选择性C-N交叉偶联反应进行了全面展望。
