Doraghi Zahra, Alinezhad Heshmatollah, Ahmadi Arezoo
Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Sci Rep. 2025 Jul 8;15(1):24432. doi: 10.1038/s41598-025-03827-6.
Metal-organic frameworks (MOFs) with high porosity have gained significant interest in organic reactions. In this study, copper-doped ZIF-8 (Cu-ZIF-8) was synthesized at room temperature, followed by oven drying at 60 °C, and subsequently employed as a highly efficient heterogeneous catalyst for both Ullmann cross-coupling and Biginelli reactions. The catalyst was characterized using various techniques, including FT-IR, XRD, BET, BJH, TGA, EDX, ICP, and SEM. These analyses confirmed that the ZIF-8 preserved its structural integrity after copper incorporation. Cu-ZIF-8 demonstrated remarkable catalytic activity in the Ullmann reaction, achieving a 93% yield with a small catalyst loading of 50 mg. In a similar manner, utilizing ethanol as a green solvent under reflux conditions along with loading 30 mg of the catalyst produced a 90% product yield in the Biginelli reaction. The synthesized products were further verified through melting point determination and NMR spectroscopy.
具有高孔隙率的金属有机框架材料（MOFs）在有机反应中引起了广泛关注。在本研究中，室温下合成了铜掺杂的ZIF-8（Cu-ZIF-8），随后在60°C下烘箱干燥，随后用作Ullmann交叉偶联反应和Biginelli反应的高效多相催化剂。使用包括FT-IR、XRD、BET、BJH、TGA、EDX、ICP和SEM在内的各种技术对催化剂进行了表征。这些分析证实，ZIF-8在掺入铜后保持了其结构完整性。Cu-ZIF-8在Ullmann反应中表现出显著的催化活性，在仅50mg的低催化剂负载量下产率达到93%。同样，在回流条件下以乙醇作为绿色溶剂并负载30mg催化剂时，Biginelli反应的产物产率达到90%。通过熔点测定和核磁共振光谱对合成产物进行了进一步验证。
