Department of Non-communicable Diseases Control and Prevention, Shaoxing Center for Disease Control and Prevention, Shaoxing, China.
Administrative Office, Shaoxing Center for Disease Control and Prevention, Shaoxing, China.
Geriatr Gerontol Int. 2024 Oct;24(10):1015-1021. doi: 10.1111/ggi.14964. Epub 2024 Aug 22.
Respiratory sarcopenia (RS) has been newly defined in a position paper by four professional organizations in Japan, and it is necessary to examine its incidence and influencing factors using this new definition. So far, little work has been undertaken; we therefore conducted a longitudinal study to fill this gap.
Our data were extracted from the China Health and Retirement Longitudinal Study. A total of 4301 older adults with complete data and without RS were chosen in 2011, of whom 3065 were followed up until 2015. The presence of low respiratory muscle strength plus low appendicular skeletal muscles mass was defined as RS based on t. A logistic regression model was used to identify the influencing factors for incident RS.
After an average of 4 years of follow-up, the cumulative incidence of RS was 5.2%, and it was particularly high in participants aged >80 (20.9%). Logistic regression analysis showed that being unmarried/divorced/widowed (odds ratio [OR] = 1.85, 95% confidence interval [CI] = 1.28-2.66, P = 0.001), not having dyslipidemia (OR = 0.35, 95% CI = 0.19-0.65, P = 0.001), having digestive disease (OR = 1.56, 95% CI = 1.11-2.19, P = 0.010), asthma (OR = 2.77, 95% CI = 1.55-4.94, P = 0.001), edentulism (OR = 1.73, 95% CI = 1.24-2.42, P = 0.001), low handgrip strength (OR = 2.82, 95% CI = 1.99-3.99, P < 0.001), or low 5-m gait speed (OR = 1.92, 95% CI = 1.23-3.01, P = 0.004) were associated with a greater likelihood of developing RS. After further adjustment for age and body mass index, asthma, edentulism, and low handgrip strength remained significant.
The identification and management of older adults with the influencing factors described above could be important in preventing RS. Geriatr Gerontol Int 2024; 24: 1015-1021.
呼吸肌减少症（RS）是由日本四个专业组织在一份立场文件中定义的新概念，因此需要使用这一定义来检验其发病率和影响因素。到目前为止，这方面的研究工作还很少，我们因此进行了一项纵向研究来填补这一空白。
我们的数据来自中国健康与养老追踪调查。2011 年共选择了 4301 名数据完整且无 RS 的老年人，其中 3065 名在 2015 年之前进行了随访。根据 t 值，将低呼吸肌力量加低四肢骨骼肌质量定义为 RS。采用 logistic 回归模型来确定发生 RS 的影响因素。
平均随访 4 年后，RS 的累积发病率为 5.2%，80 岁以上人群的发病率尤其高（20.9%）。Logistic 回归分析显示，未婚/离异/丧偶（比值比[OR] = 1.85，95%置信区间[CI] = 1.28-2.66，P = 0.001）、无血脂异常（OR = 0.35，95% CI = 0.19-0.65，P = 0.001）、患有消化系统疾病（OR = 1.56，95% CI = 1.11-2.19，P = 0.010）、哮喘（OR = 2.77，95% CI = 1.55-4.94，P = 0.001）、无牙（OR = 1.73，95% CI = 1.24-2.42，P = 0.001）、握力低（OR = 2.82，95% CI = 1.99-3.99，P < 0.001）或 5 米步行速度慢（OR = 1.92，95% CI = 1.23-3.01，P = 0.004）与发生 RS 的可能性更大相关。进一步调整年龄和体重指数后，哮喘、无牙和握力低仍然具有显著意义。
识别和管理具有上述影响因素的老年人可能对预防 RS 很重要。
