Haywood Regional Medical Center, Clyde, NC, USA.
Monmouth Medical Center, Long Branch, NJ, USA.
J Investig Med High Impact Case Rep. 2024 Jan-Dec;12:23247096241273108. doi: 10.1177/23247096241273108.
The antemortem diagnosis of secondary cardiac involvement by lymphoma remains suboptimal. Prognosis is worse with delayed diagnosis as the tumor burden increases with the multicompartment participation. Chemotherapy may improve survival, but there is a risk of mortality due to treatment-related complications, such as myocardial rupture and fatal arrhythmias. Modified chemotherapy regimens may prevent such complications, but the data are limited. We report the case of a 72-year-old woman diagnosed with diffuse large B-cell lymphoma with cardiac involvement, where early diagnosis prevented cardiac complications from the disease and its treatment as well. The aim of this case report is to highlight the fact that cardiac involvement in lymphoma is frequent and can be easily missed, leading to complications. Treatment requires an individualized approach.
淋巴瘤继发心脏侵犯的生前诊断仍不理想。由于肿瘤负荷随多腔室受累而增加,延迟诊断的预后更差。化疗可能改善生存,但由于治疗相关并发症(如心肌破裂和致命性心律失常),存在死亡风险。改良化疗方案可能预防此类并发症,但数据有限。我们报告了一例 72 岁女性,诊断为弥漫性大 B 细胞淋巴瘤伴心脏侵犯,早期诊断预防了疾病及其治疗引起的心脏并发症。本病例报告旨在强调以下事实,即淋巴瘤心脏侵犯很常见且容易被忽视,从而导致并发症。治疗需要个体化。