State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory of Specially Functional Polymeric Materials and Related Technology (Ministry of Education), Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
J Am Chem Soc. 2024 Sep 4;146(35):24189-24208. doi: 10.1021/jacs.4c05382. Epub 2024 Aug 22.
Polypeptides have the same or similar backbone structures as proteins and peptides, rendering them as suitable and important biomaterials. Amino acid -carboxyanhydrides (NCA) ring-opening polymerization has been the most efficient strategy for polypeptide preparation, with continuous advance in the design of initiators, catalysts and reaction conditions. This Perspective first summarizes the recent progress of NCA synthesis and purification. Subsequently, we focus on various initiators for NCA polymerization, catalysts for accelerating polymerization or enhancing the controllability of polymerization, and recent advances in the reaction approach of NCA polymerization. Finally, we discuss future research directions and open challenges.
多肽与蛋白质和肽具有相同或相似的骨架结构，因此它们是合适且重要的生物材料。氨基酸 - 羧酸酐（NCA）开环聚合是制备多肽的最有效策略，在引发剂、催化剂和反应条件的设计方面不断取得进展。本综述首先总结了 NCA 的合成和纯化的最新进展。随后，我们重点介绍了 NCA 聚合的各种引发剂、加速聚合或增强聚合可控性的催化剂，以及 NCA 聚合反应方法的最新进展。最后，我们讨论了未来的研究方向和开放的挑战。
