Bobrow M
Paediatric Research Unit, Prince Philip Research Laboratories, Guy's Hospital Medical School, London, England.
Exp Clin Immunogenet. 1985;2(2):97-105.
The literature on the association of heterochromatic chromosome variants and reproductive failure, manifesting as infertility or recurrent spontaneous abortion, is critically reviewed. Many methodological problems confound attempts to interpret the data. The weight of evidence is against autosomal variants having any significant effect. Although conflicting, reports on the effect of Y heterochromatin variants on both infertility (Yq-) and recurrent abortion (Yq+) are mainly positive, and further data are required in both these areas.
本文对关于异染色质染色体变异与生殖功能衰竭（表现为不孕或反复自然流产）之间关联的文献进行了批判性综述。许多方法学问题干扰了对数据的解读尝试。现有证据表明常染色体变异不太可能产生任何显著影响。关于Y异染色质变异对不孕（Yq-）和反复流产（Yq+）的影响，尽管报告结果相互矛盾，但主要还是呈阳性，这两个领域都还需要更多数据。
