• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Cortisol suppresses the LH, but not the FSH, response to gonadotropin-releasing hormone after orchidectomy.

作者信息

Ringstrom S J, Schwartz N B

出版信息

Endocrinology. 1985 Jan;116(1):472-4. doi: 10.1210/endo-116-1-472.

DOI:10.1210/endo-116-1-472
PMID:3917253
Abstract

Castration leads to a rapid increase in LH and FSH secretion, and exogenous gonadotropin-releasing hormone (GnRH) elicits supernormal secretion of LH and FSH after orchidectomy. Superimposition of adrenalectomy or pretreatment with cortisol prevents the acute castration-induced LH and FSH response seen within 24 h. The gonadotropin response to exogenous GnRH is not suppressed by adrenalectomy, indicating that adrenalectomy acts by preventing hypothalamic GnRH secretion and not by diminishing pituitary responsiveness to GnRH. Cortisol treatment severely reduces the response of LH to injected GnRH after castration, suggesting that cortisol suppression is at the pituitary level. Surprisingly, FSH secretory response to GnRH after orchidectomy is not suppressed by cortisol treatment, indicating a striking point of separate regulation of the two gonadotropins.

摘要

相似文献

1
Cortisol suppresses the LH, but not the FSH, response to gonadotropin-releasing hormone after orchidectomy.
Endocrinology. 1985 Jan;116(1):472-4. doi: 10.1210/endo-116-1-472.
2
Examination of prolactin and pituitary-adrenal axis components as intervening variables in the adrenalectomy-induced inhibition of gonadotropin response to castration.检测催乳素和垂体-肾上腺轴成分作为肾上腺切除诱导的促性腺激素对阉割反应抑制中的干预变量。
Endocrinology. 1984 Mar;114(3):880-7. doi: 10.1210/endo-114-3-880.
3
Cortisol regulates secretion and pituitary content of the two gonadotropins differentially in female rats: effects of gonadotropin-releasing hormone antagonist.皮质醇对雌性大鼠两种促性腺激素的分泌和垂体含量有不同的调节作用：促性腺激素释放激素拮抗剂的影响。
Endocrinology. 1992 Jun;130(6):3122-8. doi: 10.1210/endo.130.6.1597133.
4
Effects of castration on luteinizing hormone and follicle-stimulating hormone secretion by pituitary cells from male rats.去势对雄性大鼠垂体细胞促黄体生成素和促卵泡激素分泌的影响。
Endocrinology. 1990 May;126(5):2642-9. doi: 10.1210/endo-126-5-2642.
5
Effects of glucocorticoids on secretion of luteinizing hormone and follicle-stimulating hormone by female rat pituitary cells in vitro.糖皮质激素对体外培养的雌性大鼠垂体细胞促黄体生成素和促卵泡激素分泌的影响。
Endocrinology. 1985 Sep;117(3):849-54. doi: 10.1210/endo-117-3-849.
6
Effects of testosterone on gonadotropin subunit messenger ribonucleic acids in the presence or absence of gonadotropin-releasing hormone.在有或无促性腺激素释放激素的情况下睾酮对促性腺激素亚基信使核糖核酸的影响
Endocrinology. 1992 Feb;130(2):726-34. doi: 10.1210/endo.130.2.1370794.
7
Effects of hyperprolactinemia on the control of luteinizing hormone and follicle-stimulating hormone secretion in the male rat.高催乳素血症对雄性大鼠促黄体生成素和促卵泡生成素分泌调控的影响。
Biol Reprod. 1987 Feb;36(1):138-47. doi: 10.1095/biolreprod36.1.138.
8
Gonadotropin-releasing hormone-induced stimulation and desensitization of free alpha-subunit secretion mirrors luteinizing hormone and follicle-stimulating hormone in perifused rat pituitary cells.促性腺激素释放激素诱导的游离α亚基分泌的刺激和脱敏反映了灌流大鼠垂体细胞中促黄体生成素和促卵泡激素的情况。
Endocrinology. 1990 Nov;127(5):2364-71. doi: 10.1210/endo-127-5-2364.
9
Action kinetics of inhibin in superfused pituitary cells depend on gonadotropin-releasing hormone treatment.超灌流垂体细胞中抑制素的作用动力学取决于促性腺激素释放激素的处理。
Endocrinology. 1990 Jul;127(1):211-7. doi: 10.1210/endo-127-1-211.
10
Dexamethasone suppresses gonadotropin-releasing hormone (GnRH) secretion and has direct pituitary effects in male rats: differential regulation of GnRH receptor and gonadotropin responses to GnRH.地塞米松抑制促性腺激素释放激素（GnRH）分泌，并对雄性大鼠垂体有直接作用：GnRH受体的差异调节以及促性腺激素对GnRH的反应。
Endocrinology. 1988 Jun;122(6):2873-80. doi: 10.1210/endo-122-6-2873.

引用本文的文献

1
Diabetes as a potential compounding factor in COVID-19-mediated male subfertility.糖尿病作为新冠病毒介导的男性生育力低下的潜在复合因素。
Cell Biosci. 2022 Mar 20;12(1):35. doi: 10.1186/s13578-022-00766-x.
2
Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice.雌二醇使慢性皮质酮抑制脉冲式黄体生成素分泌，并抑制雌性小鼠中 Kiss1 神经元的激活。
Neuroendocrinology. 2020;110(6):501-516. doi: 10.1159/000502978. Epub 2019 Aug 29.
3
Corticosterone Blocks Ovarian Cyclicity and the LH Surge via Decreased Kisspeptin Neuron Activation in Female Mice.
皮质酮通过降低雌性小鼠中促性腺激素释放激素神经元的激活来阻断卵巢周期性和促黄体生成素激增。
Endocrinology. 2016 Mar;157(3):1187-99. doi: 10.1210/en.2015-1711. Epub 2015 Dec 23.
4
Effects of corticosterone and testosterone on pituitary gonadotropin content, secretion, bioactivity and messenger RNA levels in the presence or absence of GnRH in male rats.在雄性大鼠中，皮质酮和睾酮在存在或不存在促性腺激素释放激素（GnRH）的情况下对垂体促性腺激素含量、分泌、生物活性及信使核糖核酸（mRNA）水平的影响。
Endocrine. 1995 Jan;3(1):13-20. doi: 10.1007/BF02917443.
5
Sensitivity to stress-induced reproductive dysfunction is associated with a selective but not a generalized increase in activity of the adrenal axis.对应激引起的生殖功能障碍的敏感性与肾上腺轴的选择性而非一般性活动增加有关。
Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E28-36. doi: 10.1152/ajpendo.00223.2010. Epub 2010 Oct 19.
6
Serum testosterone levels after cardiac transplantation.心脏移植后的血清睾酮水平。
Transplantation. 2008 Mar 27;85(6):834-9. doi: 10.1097/TP.0b013e318166ac10.
7
Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope.雄激素、孕激素和糖皮质激素在促性腺激素细胞水平上诱导促卵泡激素β亚基基因表达。
Mol Endocrinol. 2006 Sep;20(9):2062-79. doi: 10.1210/me.2005-0316. Epub 2006 May 4.
8
Glucocorticoids inhibit gonadotropin-releasing hormone by acting directly at the hypothalamic level.糖皮质激素通过直接作用于下丘脑水平来抑制促性腺激素释放激素。
J Endocrinol Invest. 1999 Oct;22(9):666-70. doi: 10.1007/BF03343627.
9
New concepts in the regulation of hypothalamic gonadotropin releasing hormone (GnRH) secretion.下丘脑促性腺激素释放激素（GnRH）分泌调节的新概念。
J Endocrinol Invest. 1986 Oct;9(5):427-37. doi: 10.1007/BF03346958.
10
Gynecomastia associated with isolated ACTH deficiency.与孤立性促肾上腺皮质激素缺乏相关的男性乳房发育症。
J Endocrinol Invest. 1987 Apr;10(2):127-9. doi: 10.1007/BF03347173.