Orellano Pablo, Vezzani Dario
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Universidad Tecnológica Nacional, Facultad Regional San Nicolás, Buenos Aires, Argentina. E-mail:
Medicina (B Aires). 2024;84(4):734-740.
A new dengue vaccine has recently been licensed in Argentina, with the Argentine government planning to acquire it in order to develop a vaccination strategy. As the disease is gradually following a path to endemicity in some regions of the country, the incorporation of these vaccines will have the potential to tackle the growing incidence of the disease and to reduce the disease burden. However, the establishment of the vaccination programme may also be susceptible of threats related to the epidemiological shift of the disease. Selecting a specific age group for the vaccine may result in a change in the peak incidence to other age groups more susceptible to severe forms of the disease, such as children or the elderly. Furthermore, the perception of protection following vaccine introduction in one jurisdiction may reduce adherence to vector control activities, increasing the risk of virus introduction and transmission in other areas not prioritised by the vaccination strategy, and the risk of other arboviral diseases such as Zika and chikungunya fever. These and other potential limitations to be considered prior to the implementation of vaccination programmes are discussed in this article, with a series of recommendations on how to address these concerns. These recommendations can help decision makers and public health practitioners at this early stage of the vaccination programme development.
一种新型登革热疫苗最近在阿根廷获得许可，阿根廷政府计划采购该疫苗以制定疫苗接种策略。由于该病在该国一些地区正逐渐呈现地方病态势，引入这些疫苗将有可能应对该病不断上升的发病率并减轻疾病负担。然而，疫苗接种计划的制定也可能容易受到与该疾病流行病学转变相关的威胁。为疫苗选择特定年龄组可能会导致发病高峰转移到其他更容易患严重疾病形式的年龄组，如儿童或老年人。此外，在一个辖区引入疫苗后对疫苗保护作用的认知可能会降低对病媒控制活动的依从性，增加病毒在疫苗接种策略未优先考虑的其他地区传入和传播的风险，以及增加感染寨卡病毒和基孔肯雅热等其他虫媒病毒疾病的风险。本文讨论了在实施疫苗接种计划之前需要考虑的这些及其他潜在限制，并就如何解决这些问题提出了一系列建议。这些建议可在疫苗接种计划制定的早期阶段帮助决策者和公共卫生从业者。
