Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
PLoS One. 2024 Aug 22;19(8):e0306576. doi: 10.1371/journal.pone.0306576. eCollection 2024.
Extensive research has recognized the significant roles of non-coding RNAs (ncRNAs) in various cellular pathophysiological processes and their association with diverse diseases, including atrial septal defect (ASD), one of the most prevalent congenital heart diseases. This systematic review aims to explore the intricate involvement and significance of ncRNAs in the pathogenesis and progression of ASD.
Four databases (PubMed, Embase, Scopus, and the Web of Science) were searched systematically up to June 19, 2023, with no year restriction. The risk of bias assessment was evaluated using the Newcastle-Ottawa scale.
The present systematic review included thirteen studies with a collective study population of 874 individuals diagnosed with ASD, 21 parents of ASD patients, and 22 pregnant women carrying ASD fetuses. Our analysis revealed evidence linking five long ncRNAs (STX18-AS1, HOTAIR, AA709223, BX478947, and Moshe) and several microRNAs (hsa-miR-19a, hsa-miR-19b, hsa-miR-375, hsa-miR-29c, miR-29, miR-143/145, miR-17-92, miR-106b-25, and miR-503/424, miR-9, miR-30a, miR-196a2, miR-139-5p, hsa-let-7a, hsa-let-7b, and hsa-miR-486) to ASD progression, corresponding to previous studies.
NcRNAs play a crucial role in unraveling the underlying mechanisms of ASD, contributing to both biomarker discovery and therapeutic advancements. This systematic review sheds light on the mechanisms of action of key ncRNAs involved in ASD progression, providing valuable insights for future research in this field.
大量研究已经认识到非编码 RNA（ncRNAs）在各种细胞病理生理过程中的重要作用，以及它们与包括房间隔缺损（ASD）在内的多种疾病的关联，ASD 是最常见的先天性心脏病之一。本系统综述旨在探讨 ncRNAs 在 ASD 发病机制和进展中的复杂作用和意义。
系统检索了 4 个数据库（PubMed、Embase、Scopus 和 Web of Science），检索时间截至 2023 年 6 月 19 日，无年份限制。使用纽卡斯尔-渥太华量表评估偏倚风险。
本系统综述纳入了 13 项研究，共有 874 名 ASD 患者、21 名 ASD 患者的父母和 22 名携带 ASD 胎儿的孕妇纳入研究。我们的分析结果表明，有证据表明 5 个长 ncRNAs（STX18-AS1、HOTAIR、AA709223、BX478947 和 Moshe）和几个 microRNAs（hsa-miR-19a、hsa-miR-19b、hsa-miR-375、hsa-miR-29c、miR-29、miR-143/145、miR-17-92、miR-106b-25 和 miR-503/424、miR-9、miR-30a、miR-196a2、miR-139-5p、hsa-let-7a、hsa-let-7b 和 hsa-miR-486）与 ASD 进展相关，这与之前的研究结果一致。
ncRNAs 在揭示 ASD 的潜在机制方面发挥着关键作用，有助于发现生物标志物和推进治疗。本系统综述揭示了 ASD 进展中关键 ncRNAs 的作用机制，为该领域的未来研究提供了有价值的见解。
